AUDIOGRAM PROFILE OF MDR-TB PATIENTS IN HASAN SADIKIN GENERAL HOSPITAL BANDUNG
AUDIOGRAM PROFILE OF MDR-TB PATIENTS IN HASAN SADIKIN GENERAL HOSPITAL BANDUNG
DOI:
https://doi.org/10.36408/mhjcm.v8i3.613Keywords:
Ototoxicity, MDR TB, Kanamycin, SNHL, Audiometry, NeurootologyAbstract
BACKGROUND: Multidrug-resistant tuberculosis (MDR TB) is a disease condition of TB that resistant to isoniazid and rifampin, with or without resistance to other anti-tuberculosis drugs. An important problem arising from MDR TB therapy is the ototoxicity associated with use of aminoglycosides. Monitoring of hearing function is important to evaluate ototoxic effects.
OBJECTIVE: This study was conducted to determine the audiogram profile in MDR-TB patients who received kanamycin therapy in Dr. Hasan Sadikin General Hospital Bandung
METHODS: A retrospective descriptive study with a cross sectional design was conducted on MDR TB patients at Dr. Hasan Sadikin General Hospital Bandung (RSHS) Bandung. The inclusion criteria of this study is all medical records of MDR TB patients at the MDR TB polyclinic RSHS Bandung in the period January 1 - December 31 2018. Exclusions criteria were a history of tympanic membrane perforation, congenital ear abnormalities, hearing loss before therapy, and incomplete medical record data.
RESULTS: There were 97 patients in the study sample. MDR TB mostly affects the 18–34 year age group. At the end of the first month of therapy, audiogram changes were found in 9.3% of patients and in the fourth month, 22.7% of patients have sensorineural hearing loss with varying degrees.
CONCLUSION: Changes in the audiogram profile have occurred at the end of the first month of MDR TB therapy which is characterized by sensorineural hearing loss.
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References
World Health Organization (WHO). Global Tuberculosis Report 2018. 2018.
Kementrian Kesehatan RI. Situasi TBC di Indonesia. Jakarta; 2018.
World Health Organization (WHO). Consolidated Guidelines on Tuberculosis Treatment. Geneva; 2019.
Direktorat Jendral Pengendalian Penyakit dan Penyehatan Lingkungan. Pedoman Nasional Pengendalian Tuberkulosis. Katalog Dalam Terbitan?: Kementerian Kesehatan Nasional. 2014. p. 1–210.
Netter F. Head and Neck. Dalam: Netter F. Interactive Atlas of Human Anatomy. New York. Novartis. 2006. H.45
Chang KW. Ototoxicity. In: Johnson JT, Rosen CA, editors. Baileys Head and Neck Surgery Otolaryngology. 5th ed. Philadelphia: Lippincott William & Wilkins; 2014. p. 2542–55.
Weber PC, Khariwala S. Anatomy and Physiology of Hearing. In: Johnson JT, Rosen CA, editors. Baileys Head and Neck Surgery Otolaryngology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2014. p. 2253–73.
Hayes S, Salvi R, Allman B. Anatomy and Physiology of the External, Middle and Inner Ear. Handbook of Clinical Neurophysiology. 2013.
Duggal P, Sarkar M. Audiologic monitoring of multi-drug resistant tuberculosis patients on aminoglycoside treatment with long term follow-up. BMC Ear Nose Throat Disord. 2007 Nov;7:5.
Yulianti Y, Mahdiani S. Gangguan Pendengaran Pasien Tuberkulosis Multidrug Resistant. Oto Rhinolaryngologica Indones. 2015;45(2).
Reviono W, Harsini AJ, Sutanto Y. Streptomisin dan insidens penurunan pendengaran pada pasien Multidrug Resistant Tuberculosis di Rumah Sakit Dr Moewardi. J Respir Indo. 2013;33:167–72.
Heysell SK, Ahmed S, Rahman MT, Akhanda MW, Gleason AT, Ebers A, et al. Hearing loss with kanamycin treatment for multidrug-resistant tuberculosis in Bangladesh. Eur Respir J. 2018 Mar 1;51(3):1701778.
Sharma V, Bhagat S, Verma B, Singh R, Singh S. Audiological Evaluation of Patients Taking Kanamycin for Multidrug Resistant Tuberculosis. Iran J Otorhinolaryngol. 2016 May;28(86):203–8.
Ganesan, P., Schmiedge, J., Manchaiah, V., Swapna, S., Dhandayutham, S., & Kothandaraman, P. P. (2018). Ototoxicity: A Challenge in Diagnosis and Treatment. Journal of audiology & otology, 22(2), 59–68.
Lussie Rakhmawati, Ratna, Wijana. Peluang Kejadian Ototoksisitas pada Penggunaan Kanamisin dalam Pengobatan Tuberkulosis Resisten Obat Ganda Selama 1 Bulan. Majalah Kedokteran Bandung. 2015;47(4):224–30
Mils JH, Hanwalla SS, Webber PC. Anatomy and Physiology of Hearing. Dalam: Bailey BJ, Johnson JT. Head and Neck Surgery Otolaryngology Edisi ke-4. Philladelphia. Lippincott. 2006. H.1883-1903
Wahyudin W, Indrasworo D. Hubungan pemberian Kanamisin dengan kejadian ototoksik pada penderita tuberkulosis multi drug resistance; ORLI Vol. 48 No. 2 Tahun 2018.
James A. Seddon, Peter Godfrey. Hearing loss in patients on treatment for drug-resistant tuberculosis. European Respiratory Journal 2012 40: 1277-1286
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