Effects of α-Mangostin-Loaded Self-Nanoemulsion (MG-SNE) and Physical Exercise on The Reduction of Waist Circumference in Wistar Rats

Authors

  • Andreas Arie Setiawan Doctoral Study Program of Medical and Health Science, Faculty of Medicine Diponnegoro University Semarang, Indonesia, Internal Medicine Division, Faculty of Medicine Diponegoro University/ Kariadi Hospital Semarang, Indonesia, Indonesia
  • Sugiri Internal Medicine Division, Faculty of Medicine Diponegoro University/ Kariadi Hospital Semarang, Indonesia, Indonesia
  • Awal Prasetyo Anatomic Pathology Division, Faculty of Medicine Diponegoro University/ Kariadi Hospital Semarang, Indonesia, Indonesia
  • Eirin Yovita Kurniawan Medical Professional Education Study Program, Faculty of Medicine Diponegoro University Semarang, Indonesia, Indonesia
  • Dominikus Evano Putra Medical Professional Education Study Program, Faculty of Medicine Diponegoro University Semarang, Indonesia, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v11i3.1103

Keywords:

Garcinia mangostana Linn, α-Mangostin self-nanoemulsion, Physical exercise, Waist Circumference

Abstract

BACKGROUND : Waist circumference (WC) is a marker of intra-abdominal adipose tissue and a risk factor for cardiometabolic disease. A higher risk of coronary heart disease was associated with an increased WC. Garcinia mangostana Linn's anti-inflammatory activity would reduce abdominal fat deposition and WC. Additionally, Garcinia mangostana Linn's potential would increase in nanotechnology.

AIMS :  To demonstrate that WC in Wistar rats induced by an atherogenic diet can be decreased by α-Mangostin-loaded self-nanoemulsion (MG-SNE) treatment combined with physical activity.

METHOD : Experimental research with Randomized Control Trial design using a total sample of 15 male white rats (Rattus novergicus strain Wistar) weighing 300 grams and aged between 6 and 8 weeks, split into 3 groups given physical exercise for 8 weeks along with 3 different doses of medication (group K received Atorvastatin 1.44 mg once; group P1 received Garcinia mangostana Linn pericarp extract, at a dose of 800 mg/kg, divided into 3 administrations; and group P2 received MG-SNE 50 mg/kg once). Waist circumference was measured using a metline, before and after treatment.

RESULT :  WC decreased in Groups K, P1, and P2, with deltas of -5.00±21.21 mm, -12.50±24.75 mm, and -17.50±12.58 mm. The greatest decrease in WC was P2. There was no significant difference, according to the paired test between the pre-test and posttest in all groups. The p value >0.05 was determined to indicate that there were no significant differences between the groups.

CONCLUSION : WC in Wistar rats induced by an atherogenic diet can be decreased by MG-SNE treatment combined with physical exercise.

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Additional Files

Published

2024-11-29

How to Cite

1.
Setiawan AA, Sugiri S, Prasetyo A, Kurniawan EY, Putra DE. Effects of α-Mangostin-Loaded Self-Nanoemulsion (MG-SNE) and Physical Exercise on The Reduction of Waist Circumference in Wistar Rats. Medica Hospitalia J. Clin. Med. [Internet]. 2024 Nov. 29 [cited 2024 Dec. 11];11(3):257-63. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/1103

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