PENGARUH SUPLEMENTASI KOENZIM Q10 TERHADAP KADAR LAKTAT DEHIDROGENASE PENDERITA LIMFOMA NON-HODGKIN YANG MENJALANI KEMOTERAPI DI RSUP Dr.KARIADI SEMARANG

Authors

  • Farryanto Kusulistyo Bagian Ilmu Kesehatan Telinga Hidung Tenggorok – Bedah Kepala Leher, Fakultas Kedokteran Universitas Diponegoro, Semarang, Indonesia
  • Suprihati Suprihati Bagian Ilmu Kesehatan Telinga Hidung Tenggorok – Bedah Kepala Leher, Fakultas Kedokteran Universitas Diponegoro, Semarang, Indonesia
  • Willy Yusmawan Bagian Ilmu Kesehatan Telinga Hidung Tenggorok – Bedah Kepala Leher, Fakultas Kedokteran Universitas Diponegoro, Semarang, Indonesia
  • Dwi Antono Kelompok Staff Medis Telinga Hidung Tenggorok – Bedah Kepala Leher, RSUP Dr. Kariadi Semarang, Indonesia
  • Rery Budiarti Kelompok Staff Medis Telinga Hidung Tenggorok – Bedah Kepala Leher, RSUP Dr. Kariadi Semarang, Indonesia
  • Farokah Farokah Kelompok Staff Medis Telinga Hidung Tenggorok – Bedah Kepala Leher, RSUP Dr. Kariadi Semarang, Indonesia
  • Pujo Widodo Kelompok Staff Medis Telinga Hidung Tenggorok – Bedah Kepala Leher, RSUP Dr. Kariadi Semarang, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v8i2.580

Keywords:

Limfoma Non-Hodgkin prognosis koenzim q10

Abstract

LATAR BELAKANG : Peningkatan kadar LDH dikenal sebagai penanda tumor yang menggambarkan aktivitas tumor termasuk tumor sel germinal, sarkoma dan LNH. Koenzim Q10 bekerja sebagai kofaktor dalam Siklus Krebs yang berperan dalam mengatasi kondisi kekurangan ATP dalam sel melalui reaksi reduksi dan oksidasi.

TUJUAN : Membuktikan pengaruh pemberian koenzim Q10 terhadap kadar LDH penderita LNH yang mendapat kemoterapi di RSUP Dr.Kariadi, Semarang.

METODE : Penelitian intervensi dengan desain randomized pre and post test double blind control group design. Subyek yang ditentukan sebanyak 34 orang. Subjek penelitian adalah penderita LNH yang mendapat kemoterapi dengan pemberian terapi selama 21 hari. Kelompok penelitian dibagi menjadi 2, yaitu kelompok perlakuan (penderita LNH yang mendapat kemoterapi, dan koenzim Q10 100mg/hari) sebanyak 17 orang, serta kelompok kontrol (penderita LNH yang mendapat kemoterapi dan plasebo) sebagai sisanya. Analisis data dengan deskriptif dan uji hipotesis

HASIL :  Terdapat perbedaan signifikan sebelum dan setelah intervensi, dimana terjadi penurunan kadar LDH pada kelompok perlakuan sedangkan pada kelompok kontrul justru terjadi peningkatan kadar LDH.

KESIMPULAN : Kadar LDH pada pasien LNH yang diberikan koenzim Q10, lebih baik dibandingkan tanpa pemberian koenzim Q10. Terdapat perbedaan bermakna secara statistik pada penelitian ini

Kata Kunci : Limfoma Non-Hodgkin (LNH); Lactate Dehidrogenase (LDH); Koenzim Q10, prognosis

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Additional Files

Published

2021-07-15

How to Cite

1.
Kusulistyo F, Suprihati S, Yusmawan W, Antono D, Budiarti R, Farokah F, Widodo P. PENGARUH SUPLEMENTASI KOENZIM Q10 TERHADAP KADAR LAKTAT DEHIDROGENASE PENDERITA LIMFOMA NON-HODGKIN YANG MENJALANI KEMOTERAPI DI RSUP Dr.KARIADI SEMARANG. Medica Hospitalia J. Clin. Med. [Internet]. 2021 Jul. 15 [cited 2024 Nov. 21];8(2):207-12. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/580

Issue

Vol. 8 No. 2 (2021): Med Hosp; Juli 2021

Section

Original Article

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