Dry Eyes Syndrome in Patients with Type 2 Diabetes Mellitus

Authors

  • Desti Putri Setyorini Diponegoro University, Indonesia
  • Arief Wildan Department of Ophthalmology, Diponegoro University/Dr. Kariadi Hospital, Indonesia
  • Trilaksana Nugroho Department of Ophthalmology, Diponegoro University/Dr. Kariadi Hospital, Indonesia
  • Hari Peni Julianti Department of Public Health, Diponegoro University, Indonesia
  • Heri-Nugroho HS Endocrine-Metabolic Division, Department of Internal Medicine, Diponegoro University/Dr. Kariadi Hospital, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v8i3.592

Keywords:

dry eyes syndrome, risk factor, type 2 diabetes mellitus

Abstract

BACKGROUND : Type 2 diabetes mellitus patients have risk to suffer from dry eyes syndrome (DES), caused by peripheral and autonomic neuropathy, oxidative stress, and metabolic dysfunction. DES can reduce the patient’s quality of life then it could induce blindness if the patient didn’t get any therapy for DES. It is important to prevent DES by controlling its risk factors.

OBJECTIVE :  To investigate risk factors of DES in patients with type 2 diabetes mellitus.

METHOD : . This study was an analytical observational study with cross-sectional design and purposive sampling. Subjects were examined by using questionnaire and slit lamp, then followed by deep interview in some subjects. This study was also using subject’s medical record to complete the required data. Subjects were diagnosed to suffer DES if OSDI score >12 and schirmer score <10mm. Data was analyzed by using statistic software.

RESULT : . From 42 subjects, 19 subjects (45,2%) suffered from DES whereas another 23 subjects (54,8%) didn’t. There was significant relation between diabetic retinopathy (p=0.009) and DES in patients with type 2 diabetes mellitus showed by p value under 0,05 (OR 5.700, 95% CI:1.364-23.821). However, age (p=0.516), gender (p=1.000), level of knowledge (p=0.555), accessibility to health provider (p=1.000), occupation (p=0.644), economic level (p=0.105), smoke exposure (p=0.432), duration of diabetic (p=0.707), diabetic controlling (p=0.305), and history of dyslipidemia (p=0.155) had no significant relations with DES in patients with type 2 diabetes mellitus.

CONCLUSION : There is a significant relation between diabetic retinopathy and DES in patients with type 2 diabetes mellitus. Diabetic retinopathy is the most dominant risk factor among the other factors in this study.

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References

1. International Diabetes Federation. IDF diabetes atlas [Internet]. 8th ed. IDF Diabetes Atlas, 8th edition. 2017. Available from: http://fmdiabetes.org/wp-content/uploads/2018/03/IDF-2017.pdf
2. Kementerian Kesehatan RI. InfoDATIN?: Diabetes [Internet]. Jakarta; 2019. Available from: https://pusdatin.kemkes.go.id/download.php?file=download/pusdatin/infodatin/infodatin-Diabetes-2018.pdf
3. Perkumpulan Endokrinologi Indonesia (PERKENI). Konsensus pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia 2015 [Internet]. PB PERKENI; 2015. Available from: https://pbperkeni.or.id/wp-content/uploads/2019/01/4.-Konsensus-Pengelolaan-dan-Pencegahan-Diabetes-melitus-tipe-2-di-Indonesia-PERKENI-2015.pdf
4. Ozdemir M, Buyukbese M, Cetinkaya A, Ozdemir G. Risk factors for ocular surface disorders in patients with type 2 diabetes. Acta Medica Mediterr [Internet]. 2014;30(1):249–53. Available from: https://www.researchgate.net/publication/287316368
5. Ramalakshmi V, Hariramasubramanian S, Rajalakshmi A, Anandan H. Incidence of dry eye syndrome in patients with type II diabetes mellitus. Int J Sci Study [Internet]. 2017;4(12):180–2. Available from: https://www.ijss-sn.com/uploads/2/0/1/5/20153321/ijss_mar_oa38_-_2017.pdf
6. Sayin N, Kara N, Pekel G, Altinkaynak H. Effects of chronic smoking on central corneal thickness, endothelial cell, and dry eye parameters. Cutan Ocul Toxicol [Internet]. 2014;33(3):201–5. Available from: https://pubmed.ncbi.nlm.nih.gov/24147943/
7. Achtsidis V, Eleftheriadou I, Kozanidou E, Voumvourakis KI, Stamboulis E, Theodosiadis PG, et al. Dry eye syndrome in subjects with diabetes and association with neuropathy. Diabetes Care [Internet]. 2014;37(10):e210–1. Available from: https://pubmed.ncbi.nlm.nih.gov/25249675/
8. Najafi L, Malek M, Valojerdi AE, Aghili R, Khamseh ME, Fallah AE, et al. Dry eye and its correlation to diabetes microvascular complications in people with type 2 diabetes mellitus. J Diabetes Complications [Internet]. 2013;27(5):459–62. Available from: https://pubmed.ncbi.nlm.
nih.gov/23726741/
9. The definition and classification of dry eye disease: report of the definition and classification subcomittee of the international dry eyes workshop. Ocul Surf [Internet]. 2007;5(2):75–92. Available from: https://www.sciencedirect.com/science/article/pii/S1542012412700812
10. Manaviat MR, Rashidi M, Afkhami-Ardekani M, Shoja MR. Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. BMC Ophthalmol [Internet]. 2008;8:2–5. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435518/
11. Rathnakumar K, Kaliaperumal R, Ramachandran V. Prevalence of dry eye disease and its association with dyslipidemia. J Basic Clin Physiol Pharmacol [Internet]. 2017;1–5. Available from: https://pubmed.ncbi.nlm.nih.gov/29150990/
12. Shah S, Jani H. Prevalence and associated factors of dry eye: Our experience in patients above 40 years of age at a Tertiary Care Center. Oman J Ophthalmol [Internet]. 2015;8(3):151–6. Available from: https://www.researchgate.net/publication/284215990
13. Sharma A, Hindman HB. Aging?: a Predisposition to dry eyes. J Ophthalmol [Internet]. 2014;2014. Available from: http://dx.doi.org/10.1155/2014/781683
14. Riordan-Eva P, Augsburger james J. General ophthalmology. 19th ed. 2018.
15. Direktorat Pengendalian Penyakit Tidak Menular, Lingkungan DJPP dan P, RI KK. Panduan pelaksanaan hari diabetes sedunia 2016?: Eyes on diabetes. 2016.
16. Liu NN, Liu L, Li J, Sun YZ. Prevalence of and risk factors for dry eye symptom in mainland China: A systematic review and meta-analysis. J Ophthalmol [Internet]. 2014;2014:1–8. Available from: https://pubmed.ncbi.nlm.nih.gov/25386359/
17. Paiva CS De. Effects of aging in dry eye. Int Opthalmology Clin [Internet]. 2018;57(2):47–64. Available from: http://dx.doi.org/10.1155/2014/781683
18. Han SB, Hyon JY, Woo SJ, Lee JJ, Kim TH, Kim KW. Prevalence of dry eye disease in an elderly Korean population. Arch Ophthalmol [Internet]. 2011;129(5):633–8. Available from: https://jamanetwork.com/journals/jamaophthalmology/fullarticle/427286
19. Lekhanont K, Rojanaporn D, Chuck R, Vongthongsri A. Prevalence of dry eye in Bangkok, Thailand. Cornea [Internet]. 2006;25(10):1162–7. Available from: https://pubmed.ncbi.nlm.nih.gov/
17172891/
20. Jie Y, Xu L, Wu Y, Jonas B. Prevalence of dry eye among adult Chinese in the Beijing eye study. Eye [Internet]. 2009;23(3):688–93. Available from: https://pubmed.ncbi.nlm.nih.gov/18309341/
21. Yeh TN, Graham AD, Lin MC. Relationships among tear film stability, osmolarity, and dryness symptoms. Optom Vis Sci [Internet]. 2015;92(9):e264–72. Available from: https://www.ncbi.nlm.
nih.gov/pmc/articles/PMC4924532/
22. Erdem U, Ozdegirmenci O, Sobaci E, Sobaci G, Göktolga U, Dagli S. Dry eye in post-menopausal women using hormone replacement therapy. Matur Eur Menopause J [Internet]. 2007;56(3):257–62. Available from: https://pubmed.ncbi.nlm.nih.gov/17030104/
23. Notoatmodjo S. Konsep perilaku dan perilaku kesehatan. In: Promosi Kesehatan dan Perilaku Kesehatan. Jakarta: Rineka Cipta; 2014. p. 138–40.
24. Notoatmodjo S. Perilaku pencarian pelayanan kesehatan. In: Promosi Kesehatan dan Perilaku Kesehatan. Jakarta: Rineka Cipta; 2014. p. 223–5.
25. Kangari H, Eftekhari MH, Sardari S, Hashemi H, Salamzadeh J, Ghassemi-broumand M, et al. Short-term consumption of oral omega-3 and dry eye syndrome. Ophthalmology [Internet]. 2013;120(11):2191–6. Available from: http://dx.doi.org/10.1016/j.ophtha.2013.04.006
26. Thomas J, Jacob GP, Abraham L, Noushad B, Jacob GP. The effect of smoking on the ocular surface and the precorneal tear film. Australas Med J [Internet]. 2012;5(4):221–6. Available from: https://pubmed.ncbi.nlm.nih.gov/22848314/
27. Olaniyan S, Fasina O, Bekibele C, Oluwo A. Relationship between dry eye and glycosylated haemoglobin among diabetics in Ibadan, Nigeria. Pan Afr Med J [Internet]. 2019;1–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615771/
28. Pooja H, Subrahmanya B, Gowda H. Correlation of dry eye status with the duration of diabetes and the severity of diabetic retinopathy in type 2 diabetes mellitus patients. Indian J Clin Exp Ophthalmol [Internet]. 2019;5(1):12–5. Available from: https://www.researchgate.net/publication/332424669
29. Khurana G, Khurana D, Jain R. Dry eye in patients with diabetic retinopathy?: a Clinical study. Del J Ophthalmol [Internet]. 2017;27(3):190–3. Available from: http://dx.doi.org/10.7869/djo.241
30. Araujo B De, Dutra L, Lyra C, Carneiro B, Studart M, Gomes M, et al. Clinical evaluation of dry eye syndrome in patients with rroliferative diabetic retinopathy and laser therapy indication. Open Ophthalmol J [Internet]. 2019;13:1–7. Available from: https://openophthalmologyjournal.com/
VOLUME/13/PAGE/1/FULLTEXT/
31. Lv H, Li A, Zhang X, Xu M, Qiao Y, Zhang J, et al. Meta-analysis and review on the changes of tear function and corneal sensitivity in diabetic patients. Acta Ophthalmol [Internet]. 2014;92:e96–104. Available from: https://www.researchgate.net/publication/239941261
32. Butovich IA, Ham BM. Understanding and analyzing meibomian lipids-a Review. Natl Inst Heal [Internet]. 2009;33(5):405–20. Available from: https://pubmed.ncbi.nlm.nih.gov/18568877/

Additional Files

Published

2021-11-05

How to Cite

1.
Setyorini DP, Wildan A, Nugroho T, Julianti HP, HS H-N. Dry Eyes Syndrome in Patients with Type 2 Diabetes Mellitus. Medica Hospitalia J. Clin. Med. [Internet]. 2021 Nov. 5 [cited 2024 Dec. 3];8(3):326-34. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/592

Issue

Vol. 8 No. 3 (2021): Med Hosp; Nov 2021

Section

Original Article

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