Korelasi Indeks Massa Tubuh dan Tekanan Darah dengan Rasio TG/HDL pada Penderita Diabetes Mellitus Tipe 2 Etnis Jawa
Correlation of Body Mass Index and Blood Pressure with TG/HDL Ratio in Type 2 Diabetes Javanese Patients
DOI:
https://doi.org/10.36408/mhjcm.v9i3.817Keywords:
Indeks massa tubuh, tekanan darah, rasio TG/HDL, DMT2Abstract
LATAR BELAKANG: Salah satu komplikasi makrovaskuler penderita diabetes melitus tipe 2 (DMT2) yaitu penyakit jantung koroner (PJK). Kematian utama pada DMT2 disebabkan karena PJK. Rasio trigliserida (TG)/ high density lipoprotein (HDL) dapat memprediksi perkembangan PJK dan berkorelasi dengan indeks massa tubuh (IMT) dan tingkat tekanan darah.
TUJUAN: Penelitian ini bertujuan membuktikan korelasi IMT dan tekanan darah dengan rasio TG/HDL penderita DMT2 Etnis Jawa.
METODE : Sampel penelitian sejumlah 107 subjek DMT2 etnis Jawa. Data sekunder berupa rekam medis pasien DMT2 di Puskesmas, Semarang. Uji korelasi Spearman dipakai untuk menganalisis korelasi IMT dan tekanan darah dengan rasio TG/HDL dengan p<0,05.
HASIL: Pada DMT2 etnis Jawa ditemukan rerata IMT adalah 24,3 + 3,3 kg/m2 dengan mayoritas IMT obesitas (42,1%), rerata tekanan darah sistolik (138,4+19 mmHg) dan tekanan darah diastolik (80,5+8,9 mmHg) dengan mayoritas mengalami prehipertensi (46,7%). Terdapat korelasi positif lemah yang signifikan antara IMT terhadap rasio TG/HDL pada penderita DMT2 etnis Jawa (r= 0,262, p= 0,006). Tekanan darah tidak terdapat korelasi signifikan terhadap rasio TG/HDL pada penderita DMT2 etnis Jawa (r= -0,114, p=0,243,).
KESIMPULAN: Terdapat korelasi signifikan antara indeks massa tubuh (IMT) dengan rasio TG/HDL pada penderita DMT2 etnis Jawa. Sedangkan tingkat tekanan darah tidak berkontribusi terhadap rasio TG/HDL pada penderita DMT2 etnis Jawa.
KATA KUNCI: Indeks massa tubuh, tekanan darah, rasio TG/HDL, DMT2
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References
Khairani. Hari Diabetes Sedunia Tahun 2018. Pusat data dan informasi kementerian kesehatan RI: Hari diabetes sedunia tahun 2018. Jakarta: Kementerian Kesehatan RI; 2019. p. 1–8.
Dinas Kesehatan Provinsi Jawa Tengah. Profil kesehatan provinsi jawa tengah tahun 2017. Semarang: Dinas Kesehatan Provinsi Jawa Tengah; 2017.
Herningtyas EH. Prevalence and distribution of metabolic syndrome and its components among provinces and ethnic groups in Indonesia. BMC Public Health. 2019;377(19):1–12. https://doi.org/10.1186/s12889-019-6711-7
Tursinawati Y, Rohmani A, Kartikadewi A. CAPN10 SNP-19 is associated with susceptibility of type 2 diabetes mellitus: A javanese case-contro study. Indones Biomed J. 2020;12(2):109–14. DOI: 10.18585/inabj.v12i2.984
Fan W. Epidemiology in diabetes mellitus and cardiovascular disease. Cardiovasc Endocrinol. 2017;6(1):8–16. DOI: 10.1097/XCE.0000000000000116.
Ahmad Kamil Nur Zati Iwani, Muhammad Yazid Jalaludin , Ruziana Mona Wan Mohd Zin, Md Zain Fuziah, Janet Yeow Hua Hong, Yahya Abqariyah, Abdul Halim Mokhtar and WNWM. TG : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance. Int J Endocrinol. 2019;8586167:1–9. https://doi.org/10.1155/2019/8586167.
DEMİRAL M. A novel diagnostic tool in determining insulin resistance in obese children: Triglyceride / HDL ratio. J Surg Med. 2021;5(11):1144–7.
Lim TK, Lee HS, Lee YJ. Triglyceride to HDL-cholesterol ratio and the incidence risk of type 2 diabetes in community dwelling adults: A longitudinal 12-year analysis of the Korean Genome and Epidemiology Study. Diabetes Res Clin Pr [Internet]. 2020;163:1–6. Available from: https://doi.org/10.1016/j.diabres.2020.108150
Siregar J. Perbandingan profil lipid dengan hipertensi pada diabetes mellitus tipe 2 dengan atau tanpa hipertensi di RS H. Adam Malik, Medan, Indonesia. Intisari Sains Medis. 2019;10(2):354–8. doi: 10.15562/ism.v10i2.376
Yeom H, Kim HC, Lee JM, Jeon Y, Suh I. Triglyceride to high density lipoprotein cholesterol ratio among adolescents is associated with adult hypertension: The Kangwha study. Lipids Heal Dis. 2018;17(1):4–9. https://doi.org/10.1186/s12944-018-0861-y.
Jajat J, Suherman A. Indonesian Children and Adolescents’ Body Mass Index: WHO and Asia-Pacific Classification. In: 4th International Conference on Sport Science, Health, and Physical Education (ICSSHPE 2019). 2020. p. 263–6.
Whelton PK, Carey RM, Aronow WS, Casey DE, Collins KJ, Himmelfarb CD, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults a report of the American College of Cardiology/American Heart Association Task Force on Clinical pr. Hypertension. 2018;71(6):E13–115. DOI: 10.1161/HYP.0000000000000065
Tursinawati Y, Kartikadewi A, Nuriyah K, Setyoko S, Yuniastuti A. Hubungan Indeks Massa Tubuh (IMT) dengan Ankle Brachial Index (ABI) pada Pasien Diabetes Mellitus Tipe 2 Etnis Jawa. J Kesehat. 2020;11(2):197–203.
Salazar MR, Carbajal HA, Espeche WG, Aizpurúa M, Marillet AG, Leiva Sisnieguez CE, et al. Use of the triglyceride/high-density lipoprotein cholesterol ratio to identify cardiometabolic risk: Impact of obesity? J Investig Med. 2017;65(2):323–7. doi:10.1136/jim-2016-000248.
Lumbantobing AN, Suandy S, Lubis IA. Hubungan indeks massa tubuh dengan rasio TG/HDL pada pasien diabetes mellitus tipe 2. J Prima Med Sains. 2022;4(1):11–6. DOI: 10.34012/jpms.v4i1.2283.
Decroli E. Diabetes Melitus Tipe 2. 1st ed. Padang: Pusat Penerbitan Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Andalas; 2019. 4–6 p.
Borrayo G, Basurto Acevedo M de L, González-Escudero E, Diaz A, Vázquez A, Sánchez L, et al. TG/HDL-C ratio as cardio-metabolic biomarker even in normal weight women. Acta Endocrinol. 2018;14(2):261–7.doi: 10.4183/aeb.2018.261.
Wu Z, Zhou D, Liu Y, Li Z, Wang J, Han Z, et al. Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population. Cardiovasc Diabetol [Internet]. 2021;20(1):1–11. Available from: https://doi.org/10.1186/s12933-021-01330-6
Tursinawati Y, Kartikadewi A, Yuniastuti A. Rural-Urban Differences in Characteristic and Lipid Profile Among Javanese Ethnic of Type 2 Diabetes Patients. In: Advaces in Health Sciences Research. 2021. p. 136–41.
Yanuarita Tursinawati, Arum Kartikadewi RFH. Association of CAPN10 SNP-19 ( rs3842570 ) Polymorphism on Fasting Plasma Glucose , Blood Pressure and Body Mass Index of Javanese Type-2 Diabetes Patients Association of CAPN10 SNP-19 ( rs3842570 ) Polymorphism on Fasting Plasma Glucose , Blood Pressure. In: IOP Conference Series: Earth and Environmental Science. 2019. p. 1–6. doi:10.1088/1755-1315/292/1/012031.
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