Risk Factors for Mortality Among Confirmed Covid-19 Patients At RSUP Dr.Kariadi
DOI:
https://doi.org/10.36408/mhjcm.v10i1.834Keywords:
Risk factor, Confirmed COVID-19, MortalityAbstract
BACKGROUND: Coronavirus Disease 2019 (COVID-19) is a communicable disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). On March 11, 2020 the World Health Organization (WHO) declared COVID-19 as pandemic causing mortality in more than 150 countries. China reports the most case is among people aged 30 – 79 years old and male, meanwhile in Italia the most case is among patients with cardiovascular disease, diabetes, chronic diseases, hypertension, and cancer. This encourages researcher to examine risk factors causing mortality among patients with confirmed COVID-19.
METHOD: This is an observational study with multivariate analytical test. The samples involved medical records of died patients with confirmed COVID-19 at RSUP Dr.Kariadi. Risk factors being studied involved age, gender and comorbidities such as hypertension, diabetes, pneumonia, chronic obstructive pulmonary disease (COPD), heart disease, kidney disease, and cancer. Data were analyzed using multiple logistic regression with univariate, bivariate, multivariate, confounding and interaction tests.
RESULT: An increased risk for mortality was found among confirmed COVID-19 patients aged over 60 years (3.25 times), suffered from hypertension (2.09 times), pneumonia (4.77 times), cancer (11.89 times), heart disease (3.55 times), and kidney disease (5.23 times).
CONCLUSION: Risk factors involving age, hypertension, pneumonia, cancer, heart disease, and kidney disease increase risk for mortality among patients with confirmed COVID-19. The risk is heightened as patients aged older than 60 years old suffering from pneumonia and cancer simultaneously.
Downloads
References
- Kementerian Kesehatan RI. Pedoman Pencegahan dan Pengendalian Corona Virus deases (Covid-19) [Guidelines of corona virus disease (corona) prevention and control]. Kementrian Kesehatan [Internet]. 2020;5:178. Available from: https://covid19.go.id/storage/app/media/Protokol/REV-05_Pedoman_P2_COVID-19_13_Juli_2020.pdf
- KemenkesRI. Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MenKes/413/2020 Tentang Pedoman Pencegahan dan Pengendalian Corona Virus Disease 2019 (Covid-19) [Decree of Minister of Health number HK.01.07/MenKes/413/2020 on guidelines of Corona Virus Disease 2019 (Covid-19) prevention and control]. [Internet]. 2020;2019:1–207. Available from: https://covid19.go.id/storage/app/media/Regulasi/KMK No. HK.01.07-MENKES-413-2020 ttg Pedoman Pencegahan dan Pengendalian COVID-19.pdf
- Kementerian Kesehatan Republik Indonesia. Pedoman Pemulasaran Dan Penguburan Jenazah Akibat Covid-19 Di Masyarakat [Guidelines of corpse handling and funeral of Covid-19 in society]. 2020;10.
- Satgas COVID-19. Peta Sebaran COVID-19 di Indonesia [The distribution map of COVID-19 in Indonesia] [Internet]. Available from: https://covid19.go.id/peta-sebaran
- Tanggap COVID-19 Provinsi Jawa Tengah. Statistik Kasus COVID-19 Jawa Tengah [Statistics of COVID-19 in Central Java] [Internet]. Available from: https://corona.jatengprov.go.id/data
- Siaga Corona Kota Semarang. Informasi Coronavirus (COVID-19) Semarang [Coronavirus (COVID-19) information] [Internet]. Available from: https://siagacorona.semarangkota.go.id/halaman/covid19
- Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China. Jama. 2020;323(13):1239.
- Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA - J Am Med Assoc. 2020;323(18):1775–6.
- Ho FK, Petermann-Rocha F, Gray SR, Jani BD, Vittal Katikireddi S, Niedzwiedz CL, et al. Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants. PLoS One [Internet]. 2020;15(11 November):1–11. Available from: http://dx.doi.org/10.1371/journal.pone.0241824
- Kelada M, Anto A, Dave K, Saleh SN. The Role of Sex in the Risk of Mortality From COVID-19 Amongst Adult Patients: A Systematic Review. Cureus. 2020;12(8).
- Peckham H, de Gruijter NM, Raine C, Radziszewska A, Ciurtin C, Wedderburn LR, et al. Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nat Commun [Internet]. 2020;11(1):1–10. Available from: http://dx.doi.org/10.1038/s41467-020-19741-6
- Noor FM, Islam MM. Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis. J Community Health [Internet]. 2020;45(6):1270–82. Available from: https://doi.org/10.1007/s10900-020-00920-x
- Zheng Z, Peng F, Xu B, Zhao J, Liu H, Peng J, et al. Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. J Infect. 2020;81(2):e16–25.
- Graziani D, Soriano JB, Del Rio-Bermudez C, Morena D, Díaz T, Castillo M, et al. Characteristics and Prognosis of COVID-19 in Patients with COPD. J Clin Med. 2020;9(10):3259.
- Hidayani WR. Faktor Faktor Risiko Yang Berhubungan Dengan COVID 19 : Literature Review [Risk factors related to COVID-19: Literature Review]. J Untuk Mayarakat Sehat [Internet]. 2020;4(2):120–34. Available from: http://ejournal.urindo.ac.id/index.php/jukmas%0AArticle
- Li J, Guo T, Dong D, Zhang X, Chen X, Feng Y, et al. Defining heart disease risk for death in COVID-19 infection. QJM. 2020;113(12):876–82.
- Council E edta, Group W. Chronic kidney disease is a key risk factor for severe COVID-19: a call to action by the ERA-EDTA. Nephrol Dial Transplant. 2021;36(1):87–94.
- Gansevoort RT, Hilbrands LB. CKD is a key risk factor for COVID-19 mortality. Nat Rev Nephrol. 2020;16(12):705–6.
- Curigliano G. Cancer Patients and Risk of Mortality for COVID-19. Cancer Cell. 2020;(August):19–21.
- Yustinawati R, Achadi A. Risk factors for mortality in patients with COVID-19 : A Systematic Review The 7th International Conference on Public Health Solo , Indonesia , November 18-19 , 2020 | 1 The 7th International Conference on Public Health Solo , Indonesia , November 18-19 ,. 7th Int Conf Public Heal. 2020;1–11.
- Jin JM, Bai P, He W, Wu F, Liu XF, Han DM, et al. Gender Differences in Patients With COVID-19: Focus on Severity and Mortality. Front Public Heal. 2020;8(April):1–6.
- Indarwati R. Lindungi Lansia dari Covid-19 [Protecting elderly from Covid-19]. J Keperawatan Komunitas. 2020;5(1):2020.
- Harrison SL, Buckley BJR, Rivera-Caravaca JM, Zhang J, Lip GYH. Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews. Eur Hear J - Qual Care Clin Outcomes. 2021;330–9.
- Johannesen TB, Smeland S, Aaserud S, Buanes EA, Skog A, Ursin G, et al. COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway. Front Oncol. 2021;11(March):1–9.
- Li X, Xu S, Yu M, Wang K, Tao Y, Zhou Y, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol [Internet]. 2020;146(1):110–8. Available from: https://doi.org/10.1016/j.jaci.2020.04.006
- Elezkurtaj S, Greuel S, Ihlow J, Michaelis EG, Bischoff P, Kunze CA, et al. Causes of death and comorbidities in hospitalized patients with COVID-19. Sci Rep [Internet]. 2021;11(1):1–9. Available from: https://doi.org/10.1038/s41598-021-82862-5
- Gibertoni D, Reno C, Rucci P, Fantini MP, Buscaroli A, Mosconi G, et al. COVID-19 incidence and mortality in non-dialysis chronic kidney disease patients. PLoS One [Internet]. 2021;16(7 July):1–11. Available from: http://dx.doi.org/10.1371/journal.pone.0254525
- Gerayeli F V., Milne S, Cheung C, Li X, Yang CWT, Tam A, et al. COPD and the risk of poor outcomes in COVID-19: A systematic review and meta-analysis. EClinicalMedicine [Internet]. 2021;33:100789. Available from: https://doi.org/10.1016/j.eclinm.2021.100789
- Lee SC, Son KJ, Han CH, Park SC, Jung JY. Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea. Sci Rep [Internet]. 2021;11(1):1–8. Available from: https://doi.org/10.1038/s41598-021-83226-9
- Dehingia N, Raj A. Sex differences in COVID-19 case fatality: do we know enough? Lancet Glob Heal [Internet]. 2021;9(1):e14–5. Available from: http://dx.doi.org/10.1016/S2214-109X(20)30464-2
- Du Y, Zhou N, Zha W, Lv Y. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information . 2020;(January).
- Corona G, Pizzocaro A, Vena W, Rastrelli G, Semeraro F, Isidori AM, et al. Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis. Rev Endocr Metab Disord. 2021;22(2):275–96.
- Zhou Y, Yang Q, Ye J, Wu X, Hou X, Feng Y, et al. Clinical features and death risk factors in COVID-19 patients with cancer: a retrospective study. BMC Infect Dis. 2021;21(1):1–10.
- Cordero A, Santos García-Gallego C, Bertomeu-González V, Fácila L, Rodríguez-Mañero M, Escribano D, et al. Mortality associated with cardiovascular disease in patients with COVID-19. REC CardioClinics. 2021;56(1):30–8.
- Drew C, Adisasmita AC. Gejala dan komorbid yang memengaruhi mortalitas pasien positif COVID-19 di Jakarta Timur, Maret-September 2020. Tarumanagara Med J. 2021;3(3):274–83.
Additional Files
Published
How to Cite
Issue
Section
Citation Check
License
Copyright (c) 2023 Husain Junaedi, Setyo Gundi Pramudo, Sigid Kirana Lintang Bhima, Tuntas Dhanardono
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Copyrights Notice
Copyrights:
Researchers publishing manuscrips at Medica Hospitalis: Journal of Clinical Medicine agree with regulations as follow:
Copyrights of each article belong to researchers, and it is likewise the patent rights
Researchers admit that Medica Hospitalia: Journal of Clinical Medicine has the right of first publication
Researchers may submit manuscripts separately, manage non exclusive distribution of published manuscripts into other versions (such as: being sent to researchers’ institutional repository, publication in the books, etc), admitting that manuscripts have been firstly published at Medica Hospitalia: Journal of Clinical Medicine
License:
Medica Hospitalia: Journal of Clinical Medicine is disseminated based on provisions of Creative Common Attribution-Share Alike 4.0 Internasional It allows individuals to duplicate and disseminate manuscripts in any formats, to alter, compose and make derivatives of manuscripts for any purpose. You are not allowed to use manuscripts for commercial purposes. You should properly acknowledge, reference links, and state that alterations have been made. You can do so in proper ways, but it does not hint that the licensors support you or your usage.