The Effectiveness of Urinary Diversion in Patients with Cervical Cancer at Kariadi General Hospital

Authors

  • Eriawan Agung Nugroho Urology Division, Department of Surgery, Faculty of Medicine Diponegoro University/ dr. Kariadi General Hospital, Semarang, Indonesia, Indonesia https://orcid.org/0000-0002-1999-6894
  • Singgeh Setyasworo Departement of Obstetry and Gynecology, Faculty of Medicine Diponegoro University/ dr. Kariadi General Hospital, Semarang, Indonesia, Indonesia
  • Ragam Pesona Simangunsong Departement of Obstetry and Gynecology, Faculty of Medicine Diponegoro University/ dr. Kariadi General Hospital, Semarang, Indonesia, Indonesia
  • Yandhi Ari Listiyanto Departement of Obstetry and Gynecology, Faculty of Medicine Diponegoro University/ dr. Kariadi General Hospital, Semarang, Indonesia, Indonesia
  • Fajar Gemilang Purna Yudha Faculty of Medicine Diponegoro University/ dr. Kariadi General Hospital, Semarang, Indonesia, Indonesia https://orcid.org/0000-0002-3085-1047
  • Ardy Santosa Urology Division, Department of Surgery, Faculty of Medicine Diponegoro University/ dr. Kariadi General Hospital, Semarang, Indonesia, Indonesia
  • Moh Adi Soedarso Urology Division, Department of Surgery, Faculty of Medicine Diponegoro University/ dr. Kariadi General Hospital, Semarang, Indonesia, Indonesia https://orcid.org/0000-0002-9425-003X
  • Dimas Sindhu Wibisono Urology Division, Department of Surgery, Faculty of Medicine Diponegoro University/ dr. Kariadi General Hospital, Semarang, Indonesia, Indonesia https://orcid.org/0000-0003-1185-1276
  • Nanda Daniswara Urology Division, Department of Surgery, Faculty of Medicine Diponegoro University/ dr. Kariadi General Hospital, Semarang, Indonesia, Indonesia https://orcid.org/0000-0002-9396-0320
  • Sofyan Rais Addin Urology Division, Department of Surgery, Faculty of Medicine Diponegoro University/ dr. Kariadi General Hospital, Semarang, Indonesia, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v10i1.847

Keywords:

Cervical cancer, Obstructive uropathy, Urinary diversion

Abstract

BACKGROUND: Obstructive uropathy and hydronephrosis are common complications of cervical cancer. In order to provide an alternative route due to ureteral obstruction, urinary diversion was performed. Urinary diversion procedures are a therapeutic option for obstructive uropathy but their effectiveness is remain unclear. There is limited data that support urinary diversion as a treatment of ureteral obstruction to improve overall survival and progression-free survival.

AIM:  To determine the effectiveness of urinary diversion in the treatment of obstructive uropathy in cervical cancer patients.

METHOD: This study is a cross sectional involved cervical cancer patients with symptoms of obstructive uropathy. Data were obtained from medical records and limited to patients admitted from May, 2020 to May, 2021. Primary outcome was urea level, creatinine level, stage of hydronephrosis and overall survival rate of patients.

RESULT: A total of 100 patients were included in the study. In both groups, the mean age of study subjects was 52-53 years with stage IIIB being the most widely reported. There was an improvement in post creatinine in the urinary diversion group. There was a significant difference in post creatinine levels between the non-urine diversion and urinary diversion groups (p=0.039).The 12-month survival rate, in the non-urinary diversion group had a value of 86% while the urinary diversion group had a value of 94%.

CONCLUSION: This study shows that urinary diversion procedure is effective in increasing the renal function and increasing the 12-month survival of cervical cancer patients with obstructive uropathy.

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References

  1. Mattiuzzi C, Lippi G. Cancer statistics: a comparison between World Health Organization (WHO) and Global Burden of Disease (GBD). Eur J Public Health. 2020 Oct 1;30(5):1026–7.
  2. Song B, Ding C, Chen W, Sun H, Zhang M, Chen W. Incidence and mortality of cervical cancer in China, 2013. Chinese Journal of Cancer Research. 2017;29(6):471–6.
  3. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394–424.
  4. Lapitan MCM, Buckley BS. Impact of palliative urinary diversion by percutaneous nephrostomy drainage and ureteral stenting among patients with advanced cervical cancer and obstructive uropathy: A prospective cohort. Journal of Obstetrics and Gynaecology Research. 2011 Aug;37(8):1061–70.
  5. Pratiwi SE, Trianto HF, Fatinah NN, Ilmiawan MI, Fitrianingrum I, Lestari D. The Profile of Cervical Cancer Patients at Soedarso Hospital. Indonesian Journal of Cancer. 2022 Apr 1;16(1):33.
  6. Balaya V, Guani B, Magaud L, Bonsang-Kitzis H, Ngô C, Mathevet P, et al. Validation of the 2018 FIGO Classification for Cervical Cancer: Lymphovascular Space Invasion Should Be Considered in IB1 Stage. Cancers (Basel). 2020 Nov 28;12(12):3554.
  7. Rajendiran S, Gopalan U, Karnaboopathy R. Evaluation of histopathology of cervix in women with unhealthy cervix. Int J Reprod Contracept Obstet Gynecol. 2017 Feb 19;6(3):842.
  8. Putri AR, Khaerunnisa S, Yuliati I. Cervical Cancer Risk Factors Association in Patients at the Gynecologic-Oncology Clinic of Dr. Soetomo Hospital Surabaya. Indonesian Journal of Cancer. 2019 Dec 27;13(4):104.
  9. Lin M, Ye M, Zhou J, Wang ZP, Zhu X. Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies. Comput Struct Biotechnol J. 2019;17:241–50.
  10. Prapti NKG, Petpichetchian W, Chonghareon W. Nausea, Vomiting and Retching of Patients with Cervical Cancer undergoing Chemotherapy in Bali, Indonesia. Nurse Media Journal of Nursing. 2012;2(2):467–81.
  11. Roscoe JA, Morrow GR, Aapro MS, Molassiotis A, Olver I. Anticipatory nausea and vomiting. Supportive Care in Cancer. 2011 Oct 30;19(10):1533–8.
  12. Oh EG. Symptom experience in Korean adults with lung cancer. J Pain Symptom Manage. 2004 Aug;28(2):133–9.
  13. Candelaria M, Cetina L, Dueñas-González A. Anemia in Cervical Cancer Patients: Implications for Iron Supplementation Therapy. Medical Oncology. 2005;22(2):161–8.
  14. Jack WM, Tom FL. Smith and Tanagho’s General Urology. California. McGraw-Hill Education. 2020
  15. Sarfati D, Koczwara B, Jackson C. The impact of comorbidity on cancer and its treatment. CA Cancer J Clin. 2016 Jul;66(4):337–50.
  16. Nguyen-Nielsen M, Nørgaard M, Jacobsen, Borre, W. Thomsen R, Sogaard M. Comorbidity and survival of Danish prostate cancer patients from 2000–2011: a population-based cohort study. Clin Epidemiol. 2013 Nov;47.
  17. Diaz A, Baade PD, Valery PC, Whop LJ, Moore SP, Cunningham J, et al. Comorbidity and cervical cancer survival of Indigenous and non-Indigenous Australian women: A semi-national registry-based cohort study (2003-2012). PLoS One. 2018 May 8;13(5):e0196764.
  18. Setters B, Holmes HM. Hypertension in the Older Adult. Primary Care: Clinics in Office Practice. 2017 Sep;44(3):529–39.
  19. Kouba E, Wallen EM, Pruthi RS. Management of Ureteral Obstruction Due to Advanced Malignancy: Optimizing Therapeutic and Palliative Outcomes. Journal of Urology. 2008 Aug;180(2):444–50.
  20. Han CM, Tan HH, Kay N, Wang CJ, Su H, Yen CF, et al. Outcome of Laparoscopic Repair of Ureteral Injury: Follow-up of Twelve Cases. J Minim Invasive Gynecol. 2012 Jan;19(1):68–75.
  21. Friedlander JI, Duty BD, Okeke Z, Smith AD. Obstructive Uropathy from Locally Advanced and Metastatic Prostate Cancer: An Old Problem with New Therapies. J Endourol. 2012 Feb;26(2):102–9.
  22. Mishra GA, Pimple SA, Shastri SS. An overview of prevention and early detection of cervical cancers. Indian Journal of Medical and Paediatric Oncology. 2011 Jul 6;32(03):125–32.
  23. Patel K, Foster NR, Kumar A, Grudem M, Longenbach S, Bakkum-Gamez J, et al. Hydronephrosis in patients with cervical cancer: an assessment of morbidity and survival. Supportive Care in Cancer. 2015 May 23;23(5):1303–9.
  24. Pergialiotis V, Bellos I, Thomakos N, Haidopoulos D, Perrea DN, Kontzoglou K, et al. Survival outcomes of patients with cervical cancer and accompanying hydronephrosis: A systematic review of the literature. Oncol Rev. 2019 Jan 15;13(1).
  25. Goklu MR, Seckin KD, Togrul C, Goklu Y, Tahaoglu AE, Oz M, et al. Effect of Hydronephrosis on Survival in Advanced Stage Cervical Cancer. Asian Pacific Journal of Cancer Prevention. 2015 Jun 3;16(10):4219–22.
  26. Patel K, Foster NR, Kumar A, Grudem M, Longenbach S, Bakkum-Gamez J, et al. Hydronephrosis in patients with cervical cancer: an assessment of morbidity and survival. Supportive Care in Cancer. 2015 May 23;23(5):1303–9.
  27. Dienstmann R, da Silva Pinto C, Pereira MT, Small IA, Ferreira CG. Palliative Percutaneous Nephrostomy in Recurrent Cervical Cancer: A Retrospective Analysis of 50 Consecutive Cases. J Pain Symptom Manage. 2008 Aug;36(2):185–90.
  28. Rose PG, Ali S, Whitney CW, Lanciano R, Stehman FB. Impact of hydronephrosis on outcome of stage IIIB cervical cancer patients with disease limited to the pelvis, treated with radiation and concurrent chemotherapy: A Gynecologic Oncology Group study. Gynecol Oncol. 2010 May;117(2):270–5.
  29. Song S, Rudra S, Hasselle MD, Dorn PL, Mell LK, Mundt AJ, et al. The effect of treatment time in locally advanced cervical cancer in the era of concurrent chemoradiotherapy. Cancer. 2013 Jan 15;119(2):325–31.
  30. Choudhury S, Pal DK, Jain P. Role of Urinary Diversion in Optimization of Patients of Advanced Cervical Cancer with Obstructive Uropathy. Scholars Journal of Applied Medical Sciences. 2017;5(7C):2679–84.

Additional Files

Published

2023-03-31

How to Cite

1.
Nugroho EA, Setyasworo S, Simangunsong RP, Listiyanto YA, Yudha FGP, Santosa A, Soedarso MA, Wibisono DS, Daniswara N, Addin SR. The Effectiveness of Urinary Diversion in Patients with Cervical Cancer at Kariadi General Hospital. Medica Hospitalia J. Clin. Med. [Internet]. 2023 Mar. 31 [cited 2024 Nov. 21];10(1):69-75. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/847

Issue

Vol. 10 No. 1 (2023): Med Hosp; March 2023

Section

Original Article

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Copyright (c) 2023 Eriawan Agung Nugroho, Singgeh Setyasworo, Ragam Pesona Simangunsong, Yandhi Ari Listiyanto, Fajar Gemilang Purna Yudha, Ardy Santosa, Moh Adi Soedarso, Dimas Sindhu Wibisono, Nanda Daniswara, Sofyan Rais Addin

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