Correlation Between Portal Venous Dimensions And Liver Stiffness In Patients Of Child Pugh A Cirrhosis

Authors

  • Antonius Gunawan Santoso Departement of Radiology Faculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, Indonesia, Indonesia
  • Nala Khodlil Mubarok Departement of Radiology Faculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, Indonesia, Indonesia
  • Maya Nuriya Widyasari Departement of Radiology Faculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, Indonesia, Indonesia
  • Hery Djagat Purnomo Sub Devision Gastroenterohephatology Faculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, Indonesia, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v10i1.899

Keywords:

Liver stiffness, portal vein diameter, portal vein velocity, child-pugh A

Abstract

BACKGROUND: Liver cirrhosis is an end-stage liver disease characterized by pathologic fibrosis and regenerative nodules with resultant liver dysfunction. The diagnostic hallmark of portal hypertension is slow flow velocities in addition to the increased caliber of the mean portal vein. That is, the diagnosis of portal hypertension requires the measurement of mean portal velocity and portal diameter, and the correlation between cirrhosis and mean portal velocity and port diameter is the correlation between liver cirrhosis and its complications.
OBJECTIVE: To analyze the correlation between portal vein dimensions and liver stiffness in patients of Child-Pugh A cirrhosis.
METHOD: This study was a cross-sectional study on 30 subjects with Child-Pugh A liver cirrhosis. The subjects of this research are patients who come to the Radiology Department of the Dr. Kariadi Hospital in Semarang for point shear wave elastography and abdominal ultrasound examination from January to December 2022. Spearman test correlation was used for the analysis.
RESULT: Spearman test showed no correlation between liver stiffness and portal vein diameter (p=0.250, r= -0.217), liver stiffness and mean portal vein velocity (p=0.883, r= -0.028), and portal vein diameter with mean venous velocity in Child-Pugh A liver cirrhosis (p = 0.979, r = 0.005)

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References

  1. Wang J, Wang Q, Yu G et all. Correlation Between Liver Stiffness Measured by Shear Wave Elastography And Child-Pugh Classification. J UltrasoundMed 2018; 00:00–00
  2. Hoodeshenas S, Yin M, Venkatesh Magnetic Resonance Elastography of Liver Current Update. 2018;Volume 27: 319-333
  3. Jansen C, Bogs C, Verlinden W, Thiele M, Möller P, Görtzen J, Lehmann J, Vanwolleghem T, Vonghia L, Praktiknjo M, Chang J, Krag A, Strassburg CP, Francque S, Trebicka J. Jansen C, et al. Liver Int. 2017 Mar;37(3):396-405. doi: 10.1111/liv.13243. Epub 2016 Sep 25. Liver Int. 2017. PMID: 27569696
  4. Bhargava SK. Textbook of Color Doppler Imaging second edition. Jaypee brothers Medical Publishers (P) Ltd. New Delhi, India
  5. Hong WK, Kim MY, Baik SK, Shin SY, et all. The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data. Clin Mol Hepatol 2013; 19: 370-375 [PMID: 24459641 DOI: 10.3350/ cmh.2013.19.4.370]
  6. Sudirman I. Kesesuaian Gambaran Ultrasonografi Transabdominal Duplex Hepar Dan Lien Serta Transient Elastography (Fibroscan) Dalam Menilai Fibrosis Hepar Pada Pasien Hepatitis Virus Kronik. Fakultas Kedokteran Universitas Hasanuddin Makassar. 2018
  7. Gunawan Y, Murtala B and Asriyani S. Evaluasi Shear Wave Elastography, Fibroscan dan Kecepatan Aliran Vena Porta pada Pasien Non-Alcoholic Fatty Liver Disease. Jurnal Biomedik: JBM 2022; 14(1): 10-16
  8. Leao J, Brock M, Castilho M, Scariot A, et all. Non-Invasive Assessment of Fibrosis Using Color Doppler Ultrasound in Patients with Hepatitis C Virus in the Amazon Rainforest, Brazil. The American Society of Tropical Medicine and Hygiene. 2012. pp. 273–279
  9. Amin AI, Zaghloul SG, Lakouz et all. Effect Of Non-Selective Beta Blockers On Esophageal Varices And Portal Vein Diameter In Cirrhotic Hcv Patients. U.M.J.Vol. 24; No.5 September.;2018: 449-455
  10. Zaghloul S.G, Wahab E.A, Seleem W.M et all. Impact of non-selective beta blockers on portal hypertension and hepatic elasticity in hepatitis C virus-related liver cirrhosis. Drug Discoveries & Therapeutics. 2019; 13(2):108-113.
  11. Ahmed, M. Assessment of normal portal vein diameter and velocity using ultrasound. Clin Radiol Imag. 2019. J; 3: 000143
  12. Luo W, Meng Y, JI H.L et all. Spironolactone Lowers Portal Hypertension by Inhibiting Liver Fibrosis, ROCK-2 Activity and Activating NO/PKG Pathway in the Bile-Duct-Ligated Rat. PLoS ONE 7(3). 2012: e34230. doi:10.1371/journal.pone.0034230
  13. Boursier J, Isselin G, Fouchard- Hubert I, Oberti F, Dib N, Lebigot J, et al. Acoustic radiation force impulse: A new ultrasonographic technology for the widespread noninvasive diagnosis of liver fibrosis. European Journal of Gastroenterology & Hepatology. 2010;22(9):1074-1084
  14. Sebastian Mueller & Laurent Sandrin. Liver stiffness: a novel parameter for the diagnosis of liver disease, Hepatic Medicine: Evidence and Research. 2010;49-67, DOI: 10.2147/hmer.s7394
  15. Wu, L., Shen, Y., & Li, F. Non-invasive diagnosis of liver fibrosis: A review of current imaging modalities. Gastroenterología y Hepatología (English Edition). 2020;43(4), 211–221. doi:10.1016/j.gastre.2019.11.006
  16. Zaki, M., Hazem, M. & Elsamman, M. Shear wave elastography in assessment of liver stiffness and prediction of gastro-esophageal varices in patients with liver cirrhosis. Egypt J Radiol Nucl Med 50, 16 (2019). https://doi.org/10.1186/s43055-019-0015-x
  17. Iranpour P, Lall C, Houshyar R, Helmy M, Yang A, Choi JI, et al. Altered Doppler flow patterns in cirrhosis patients: an overview. Ultrasonography. 2016 Jan;35(1):3-12.
  18. Tsoris A, Marlar CA. Use Of The Child Pugh Score In Liver Disease. In: StatPearls. StatPearls Publishing, Treasure Island (FL); 2022. PMID: 31194448.
  19. Singh, S., Fujii, L. L., Murad, M. H., Wang, Z., Asrani, S. K., Ehman, R. L., Talwalkar, J. A. Liver Stiffness Is Associated With Risk of Decompensation, Liver Cancer, and Death in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis. Clinical Gastroenterology and Hepatology, 2013;11(12), 1573–1584.e2. doi:10.1016/j.cgh.2013.07.034
  20. Perazzo, H., Veloso, V. G., Grinsztejn, B., Hyde, C., & Castro, R.. Factors That Could Impact on Liver Fibrosis Staging by Transient Elastography. International Journal of Hepatology, 2015, 1–5. doi:10.1155/2015/624596

Additional Files

Published

2023-03-31

How to Cite

1.
Santoso AG, Mubarok NK, Widyasari MN, Purnomo HD. Correlation Between Portal Venous Dimensions And Liver Stiffness In Patients Of Child Pugh A Cirrhosis. Medica Hospitalia J. Clin. Med. [Internet]. 2023 Mar. 31 [cited 2024 Dec. 3];10(1):102-6. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/899

Issue

Vol. 10 No. 1 (2023): Med Hosp; March 2023

Section

Original Article

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Copyright (c) 2023 Nala Khodlil Mubarok, Antonius Gunawan Santoso, maya Widyasari, Hery Djagat Purnomo

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