Penyakit Stroke dan Infeksi Corona Virus Disease 2019 (COVID-19): Sebuah Tinjauan Literatur

Authors

  • Aditya Kurnianto Departemen Neurologi, RSUP Dr. Kariadi Semarang, Indonesia
  • Dodik Tugasworo Departemen Neurologi, RSUP Dr. Kariadi Semarang, Indonesia
  • Retnaningsih Retnaningsih Departemen Neurologi, RSUP Dr. Kariadi Semarang, Indonesia
  • Yovita Andhitara Departemen Neurologi, RSUP Dr. Kariadi Semarang, Indonesia
  • Rahmi Ardhini Departemen Neurologi, RSUP Dr. Kariadi Semarang, Indonesia
  • Fatiha Sri Utami Tamad Program Studi Ilmu Penyakit Saraf, Fakultas Kedokteran Universitas Diponegoro Semarang, Indonesia
  • Locoporta Agung Program Studi Ilmu Penyakit Saraf, Fakultas Kedokteran Universitas Diponegoro Semarang, Indonesia
  • Jethro Budiman Program Studi Ilmu Penyakit Saraf, Fakultas Kedokteran Universitas Diponegoro Semarang, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v7i1A.458

Keywords:

COVID-19, neurologi, stroke

Abstract

Latar belakang: Corona virus disease 2019 (COVID-19) adalah suatu penyakit yang disebabkan oleh virus severe acute resporatory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 awalnya diketahui menyerang saluran pernapasan, namun sekarang ini manifestasi klinisnya beragam termasuk manifestasi kelainan saraf/neurologis. Kelainan neurologis yang perlu mendapat perhatian khusus karena morbiditas dan mortalitasnya yang dapat ditekan bila ditangani secara tepat waktu adalah kasus penyakit serebrovaskular/stroke. Tujuan dari tinjauan literatur ini adalah mengkaji secara teori berdasarkan literatur tentang hubungan infeksi COVID-19 dan stroke.

Metode: Review literatur

Pembahasan: Stroke pada COVID-19 berhubungan dengan koagulopati, antibodi antifosfolipid, dan vaskulitis. Manifestasi klinis, pemeriksaan penunjang, dan penanganan pada kasus stroke dengan COVID-19 butuh mendapat perhatian khusus. Penanganan pada stroke dengan COVID-19 difokuskan kepada keselamatan pasien dan keamanan tenaga kesehatan.

Simpulan: Vasokontriksi serebral, peradangan saraf, stres oksidatif, dan trombogenesis dapat berkontribusi terhadap patofisiologi stroke selama infeksi COVID-19. Protokol perawatan di rumah sakit harus dimodifikasi untuk memberikan perawatan individual yang lebih baik untuk pasien stroke disertai COVID-19 dan keamanan bagi tenaga kesehatan.

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References

1. Li H, Liu SM, Yu XH, Tang SL, Tang CK. Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents. 2020;55(5):1–8.
2. Lotfi M, Hamblin MR, Rezaei N. COVID-19: Transmission, prevention, and potential therapeutic opportunities. Clin Chim Acta. 2020;508:254–66.
3. Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res. 2020;24:91–8.
4. Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clin Immunol. 2020;215:1–7.
5. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;109:1–4.
6. Fu B, Chen Y. The 2019 novel coronavirus disease with secondary ischemic stroke: two cases report. 2019;1–12.
7. Avula A, Nalleballe K, Narula N, Sapozhnikov S, Dandu V, Toom S, et al. COVID-19 presenting as stroke. Brain Behav Immun. 2020;87:115–9.
8. WHO. Coronavirus disease 2019 (COVID-19) Situation report. WHO. 2020.
9. Zhao J, Rudd A, Liu R. Challenges and Potential Solutions of Stroke Care During the Coronavirus Disease 2019 (COVID-19) Outbreak. Stroke. 2020;51(5):1356–7.
10. Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 2020;10(2):102–8.
11. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Eng J Med. 2020;382(8):727–33.
12. Wu F, Zhao S, Yu B, Chen Y-M, Wang W, Hu Y, et al. Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China. bioRxiv. 2020;651–8.
13. Divani AA, Andalib S, Napoli M Di, Lattanzi S, Hussain MS, Biller J, et al. Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights. J Stroke Cerebrovasc Dis. 2020;29(8):1–12.
14. Baig AM. Neurological manifestations in COVID-19 caused by SARS-CoV-2. CNS Neurosci Ther. 2020;26(5):499–501.
15. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683–90.
16. Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review. Clin Neurol Neurosurg. 2020;194:1–7.
17. Pinzon RT, Wijaya VO, Buana RB, Al Jody A, Nunsio PN. Neurologic Characteristics in Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis. Front Neurol. 2020;11:1–11.
18. Wang HY, Li XL, Yan ZR, Sun XP, Han J, Zhang BW. Potential neurological symptoms of COVID-19. Ther Adv Neurol Disord. 2020;13:1–2.
19. Whittaker A, Anson M, Harky A. Neurological Manifestations of COVID-19: A systematic review and current update. Acta Neurol Scand. 2020;142(1):14–22.
20. Hassett C, Gedansky A, Mays M, Uchino K. Acute ischemic stroke and COVID-19. Cleve Clin J Med. 2020;19–21.
21. Dafer RM, Osteraas ND, Biller J. Acute Stroke Care in the Coronavirus Disease 2019 Pandemic. J Stroke Cerebrovasc Dis. 2020;29(7):1–4.
22. Khosravani H, Rajendram P, Notario L, Chapman MG, Menon BK. Protected Code Stroke: Hyperacute Stroke Management during the Coronavirus Disease 2019 (COVID-19) Pandemic. Stroke. 2020;1891–5.
23. Markus HS, Brainin M. COVID-19 and stroke—A global World Stroke Organization perspective. Int J Stroke. 2020;15(4):361–4.
24. Qureshi AI, Abd-Allah F, Alsenani F, Aytac E, Borhani-Haghighi A, Ciccone A, et al. Management of acute ischemic stroke in patients with COVID-19 infection: Report of an international panel. Int J Stroke. 2020;0(0):1–15.
25. Li Y, Wang M, Zhou Y, Chang J, Xian Y, Mao L, et al. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Lancet. 2020.
26. Berekashvili K, Dmytriw AA, Vulkanov V, Agarwal S, Khaneja A, Turkel-Parella D, et al. Etiologic Subtypes of Ischemic Stroke in SARS-COV-2 Virus patients. medRxiv. 2020.
27. Guan W-J, Ni Z-Y, Hu Y, Liang W-H, Ou C-Q, He J-X, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Eng J Med. 2020;(18):1–13.
28. Klok FA, Kruip MJHA, Meer NJMVD, Arbous MS, Gommers DAMPJ, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145–7.
29. Sanyasi RDLR, Pramudita EA. Ischemic stroke in coronavirus disease 19 (COVID-19) positive patient: a case report. J Med Sci. 2020;52(3):30–6.
30. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–62.
31. Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, et al. Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. N Eng J Med. 2020;38:1–3.
32. Cavalli E, Bramanti A, Ciurleo R, Tchorbanov A, Giordano A, Fagone P, et al. Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review). Int J Mol Med. 2020;1–10.
33. Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395:1417–8.
34. Almashat SA. Vasculitis in COVID-19: A Literature Review. J vasc. 2020;6(1):1–5.
35. Hanafi R, Roger PA, Perin B, Kuchcinski G, Deleval N, Dallery F, et al. COVID-19 Neurologic Complication with CNS Vasculitis-Like Pattern. AJNR Am J Neuroradiol. 2020;1–4.
36. Schett G, Sticherling M, Neurath MF. COVID-19: risk for cytokine targeting in chronic inflammatory diseases? Nat Rev Immunol. 2020;20(5):271–2.
37. Susilo A, Rumende CM, Pitoyo CW, Santoso WD, Yulianti M, Herikurniawan H, et al. Coronavirus Disease 2019: Tinjauan Literatur Terkini. J Penyakit Dalam Indones. 2020;7(1):45–67.
38. Kelley N, Jeltema D, Duan Y, He Y. The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int J Mol Sci. 2019;20(13):1–24.
39. Shimizu H, Sakimoto T, Yamagami S. Pro-inflammatory role of NLRP3 inflammasome in experimental sterile corneal inflammation. Sci Rep. 2019;9(1):1–11.
40. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506.
41. Bohmwald K, Gálvez NMS, Ríos M, Kalergis AM. Neurologic Alterations Due to Respiratory Virus Infections. Front Cell Neurosci. 2018;12:1–15.
42. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271–80.
43. Arroja MMC, Reid E, McCabe C. Therapeutic potential of the renin angiotensin system in ischaemic stroke. Exp Transl Stroke Med. 2016;8(8):1–14.
44. Sharifi-razavi A, Karimi N, Zarvani A, Baghbanian SM. Ischemic stroke associated with novel coronavirus 2019: a report of three cases. Int J Neurosci. 2020;1–5.
45. Beyrouti R, Adams ME, Benjamin L, Cohen H, Farmer S F, Goh Y Y, et al. Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychriatry. 2020;1–3.
46. Moshayedi P, Ryan TE, Mejia LLP, Nour M, Liebeskind DS. Triage of Acute Ischemic Stroke in Confirmed COVID-19: Large Vessel Occlusion Associated With Coronavirus Infection. Front Neurol. 2020;11:10–2.

Additional Files

Published

2020-08-28

How to Cite

1.
Kurnianto A, Tugasworo D, Retnaningsih R, Andhitara Y, Ardhini R, Tamad FSU, Agung L, Budiman J. Penyakit Stroke dan Infeksi Corona Virus Disease 2019 (COVID-19): Sebuah Tinjauan Literatur. Medica Hospitalia J. Clin. Med. [Internet]. 2020 Aug. 28 [cited 2024 Nov. 23];7(1A):241-8. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/458

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