Serum Protein D Surfactant Level Based on Length of Exposure in Workers at the Supit Urang Waste Disposal Site, Malang

Authors

  • Zata Dini Pulmonolgy and Respiratory Medicine Division, Medical Faculty of Brawijaya University/Central General Hospital of Saiful Anwar East Java, Indonesia
  • Tri Wahju Astuti Pulmonolgy and Respiratory Medicine Division, Medical Faculty of Brawijaya University/Central General Hospital of Saiful Anwar East Java, Indonesia
  • Rezki Tantular Pulmonolgy and Respiratory Medicine Division, Medical Faculty of Brawijaya University/Central General Hospital of Saiful Anwar East Java, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v12i1.1218

Keywords:

Plasma Protein D Surfactant, waste workers, long exposure, high risk

Abstract

BACKGROUND: Waste collectors are at risk of developing lung disease due to exposure to bioaerosols from organic and inorganic materials. The function of surfactant protein D (SP-D) is as innate immunity that protects the lungs.  Exposure to bioaerosols in landfills causes inflammatory reactions which can increase the permeability of the blood-lung barrier. As a result, SP-D will leak into the plasma.

AIMS: This study aims to analyze serum SP-D levels in relation to length of exposure in waste collectors.

METHOD: This analytical, cross-sectional study was done in a Supit Urang waste disposal site, Malang, Indonesia. Samples for serum SP-D analysis were taken from peripheral blood samples and analyzed with ELISA technique.

RESULT: There were 68 subjects, consisting of 24 subjects with exposure duration of 5 years, 14 subjects of 5-10 years, and 30 subjects with exposure of 10 years. The number of smokers and non-smokers were 36 and 32 subjects respectively. Significant differences in SP-D serum levels were found between different exposure durations, particularly with exposure of more than 5years. A significant positive correlation was obtained between serum SP-D levels and exposure duration (r = 0,585; p = 0,000). Meanwhile, there was no significant difference in serum Sp-D levels based on smoking status (p=0.112).

CONCLUSION: Length of exposure significantly affected SP-D serum levels in waste workers, especially with exposure of more than 5 years.

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Additional Files

Published

2025-03-27

How to Cite

1.
Dini Z, Astuti TW, Tantular R. Serum Protein D Surfactant Level Based on Length of Exposure in Workers at the Supit Urang Waste Disposal Site, Malang. Medica Hospitalia J. Clin. Med. [Internet]. 2025 Mar. 27 [cited 2025 Apr. 4];12(1):9-22. Available from: https://medicahospitalia.rskariadi.co.id/index.php/mh/article/view/1218

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