Correlation between Maximal Inspiratory Pressure and the Sit-to-Stand Test in Post-COVID-19 Patients

Authors

  • Siti Chandra Widjanantie Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia https://orcid.org/0000-0003-0889-7740
  • Erick Ary Tjawanta Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Triya Damayanti Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Cleopas Martin Rumende Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Andari Perwira Putri General Practitioner, National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia
  • Heidy Agustin Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Erna Setiawati Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
  • Sri Wahyudati Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v12i3.1382

Keywords:

COVID-19, Diaphragm, Maximal Inspiratory Pressure, Sit-to-Stand Test

Abstract

BACKGROUND: Coronavirus Disease 2019 (COVID-19) can lead to long-lasting complications such as ongoing respiratory issues and functional impairments. Damage to the alveoli and respiratory muscles, particularly the diaphragm, may result in lower maximal inspiratory pressure (MIP) and decreased physical performance. Although prior studies have examined the connection between MIP and functional tests in various respiratory conditions, research focusing on post-COVID-19 populations, particularly in Indonesia, is scarce.

AIMS:  To investigate the correlation between Maximal Inspiratory Pressure (MIP) and 30-second Sit-to-Stand (30s STS) test performance in adult post-COVID-19 patients.

METHOD: A cross-sectional study was conducted at two tertiary hospitals in Jakarta, Indonesia, involving 40 adults post-COVID-19 patients aged 18–59 years. Participants underwent clinical screening, spirometry, MIP measurement using the MicroRPM device, and the 30s STS test. Pearson correlation analysis was used for normally distributed variables with significance set at p < 0.05.

RESULT:  The average MIP was 79.03 ± 26.68 cmH₂O, while the mean score for the 30s STS test was 12.78 ± 2.47 repetitions. Spirometric measurements revealed an average FEV₁ of 2.23 ± 0.57 L, FVC of 2.84 ± 0.69 L, and an FEV₁/FVC ratio of 81.19%. A moderate positive correlation between MIP and 30s STS performance was identified (r = 0.515, p = 0.001).

CONCLUSION: There is a significant moderate correlation between MIP and 30s STS performance among post-COVID-19 patients, suggesting that simple functional tests can be effective tools for assessing respiratory muscle strength and informing rehabilitation strategies in clinical environments.

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References

1.     Kementerian Kesehatan Republik Indonesia. Pedoman pencegahan dan pengendalian coronavirus disease (COVID-19) revisi kelima. Jakarta; 2020. 
2.     Kementerian Kesehatan Republik Indonesia. Panduan pelaksanaan pemeriksaan, pelacakan, karantina, dan isolasi dalam rangka percepatan pencegahan dan pengendalian coronavirus disease 2019 (COVID-19). Jakarta; 2021. 
3.     Kementerian Kesehatan Republik Indonesia. Pedoman pencegahan dan pengendalian coronavirus disease 2019 (COVID-19). Jakarta; 2020. 
4.     Verduri A, Tonelli R, Donatelli P, Hewitt J, Guaraldi G, Milić J, et al. Respiratory Muscle Dysfunction and Associated Risk Factors Following COVID-19-Related Hospitalisation. Life. 2025 Jan 28;15(2):194. 
5.     Salem AM, Al Khathlan N, Alogily M, Alharbi M, Alsubaei N, AlOuhali H, et al. Respiratory muscle weakness, reduced exercise capacity, and impaired lung functions in long-term post-COVID-19 patients. Electronic Journal of General Medicine. 2025 May 1;22(3):em646. 
6.     Severin R, Arena R, Lavie CJ, Bond S, Phillips SA. Respiratory Muscle Performance Screening for Infectious Disease Management Following COVID-19: A Highly Pressurized Situation. Am J Med. 2020 Sep;133(9):1025–32. 
7.     Faria N, Oliveira T, Pinto P, Almeida V, Carvalho R, José Fernandes M, et al. Role of the one-minute sit-to-stand test in the diagnosis of post COVID-19 condition: a prospective cohort study. Jornal Brasileiro de Pneumologia. 2023 Apr 18;e20230027. 
8.     Srithawong A, Poncumhak P, Promsrisuk T, Amput P. Cut-off values of one-minute sit-to-stand test for determining physical performance in mild-post-COVID-19 individuals. Canadian Journal of Respiratory Therapy. 2024 Oct 10;60. 
9.     Azer SA. COVID-19: pathophysiology, diagnosis, complications and investigational therapeutics. New Microbes New Infect. 2020 Sep;37:100738. 
10.     Kordzadeh-Kermani E, Khalili H, Karimzadeh I. Pathogenesis, Clinical Manifestations and Complications of COVID-19. Future Microbiol. 2020 Sep 27;15(13):1287–305. 
11.     Inui S, Kurokawa R, Nakai Y, Watanabe Y, Kurokawa M, Sakurai K, et al. Comparison of Chest CT Grading Systems in COVID-19 Pneumonia. Radiol Cardiothorac Imaging. 2020 Dec 1;2(6):e200492. 
12.     Vinícius Santana A, Daiane Fontana A, Pitta F. Pulmonary rehabilitation after COVID-19. Jornal Brasileiro de Pneumologia. 2021;47(1):e20210034–e20210034. 
13.     Zampogna E, Paneroni M, Belli S, Aliani M, Gandolfo A, Visca D, et al. Pulmonary Rehabilitation in Patients Recovering from COVID-19. Respiration. 2021;100(5):416–22. 
14.     Tabacof L, Tosto-Mancuso J, Wood J, Cortes M, Kontorovich A, McCarthy D, et al. Post-acute COVID-19 Syndrome Negatively Impacts Physical Function, Cognitive Function, Health-Related Quality of Life, and Participation. Am J Phys Med Rehabil. 2022 Jan;101(1):48–52. 
15.     Plaza M de la, Sevilla GGP de. Respiratory muscle sequelae in young university students infected by coronavirus disease 2019: an observational study. Rev Assoc Med Bras. 2022 Feb;68(2):245–9. 
16.     Severin R, Franz CK, Farr E, Meirelles C, Arena R, Phillips SA, et al. The effects of COVID-19 on respiratory muscle performance: making the case for respiratory muscle testing and training. European Respiratory Review. 2022 Dec 31;31(166):220006. 
17.     Amput P, Tapanya W, Wongphon S, Naravejsakul K, Sritiyot T. Test–Retest Reliability and Minimal Detectable Change of the 6-Minute Step Test and 1-Minute Sit-to-Stand Test in Post-COVID-19 Patients. Adv Respir Med. 2025 Sep 8;93(5):33. 
18.     Romaszko-Wojtowicz A, Szalecki M, Olech K, Doboszyńska A. Assessment of the Function of Respiratory Muscles in Patients after COVID-19 Infection and Respiratory Rehabilitation. Trop Med Infect Dis. 2023 Jan 12;8(1):57. 
19.     Xavier DM, Abreu RAL, Corrêa FG, Silva WT, Silva SN, Galvão EL, et al. Effects of respiratory muscular training in post-covid-19 patients: a systematic review and meta-analysis of randomized controlled trials. BMC Sports Sci Med Rehabil. 2024 Aug 27;16(1):181. 
20.     Murray and Nadel’s Textbook of Respiratory Medicine. Elsevier; 2016. 
21.     Prestes G da S, Simon CS, Walz R, Ritter C, Dal-Pizzol F. Respiratory Outcomes After 6 Months of Hospital Discharge in Patients Affected by COVID-19: A Prospective Cohort. Front Med (Lausanne). 2022 Mar 7;9. 
22.     Ortiz-Ortigosa L, Gálvez-Álvarez P, Viñolo-Gil MJ, Rodriguez-Huguet M, Góngora-Rodríguez J, Martín-Valero R. Effectiveness of pulmonary rehabilitation programmes and/or respiratory muscle training in patients with post-COVID conditions: a systematic review. Respir Res. 2024 Jun 19;25(1):248. 
23.     del Corral T, Fabero-Garrido R, Plaza-Manzano G, Fernández-de-las-Peñas C, Navarro-Santana M, López-de-Uralde-Villanueva I. Home-based respiratory muscle training on quality of life and exercise tolerance in long-term post-COVID-19: Randomized controlled trial. Ann Phys Rehabil Med. 2023 Feb;66(1):101709. 
24.     Schreiber A, Gosselink R. Inspiratory Muscle Training in Patients with Post–COVID-19 Condition: Considerations on Efficacy, Safety, and Patient Perception. Am J Respir Crit Care Med. 2024 Sep 1;210(5):537–9. 
25.     Eibel B. Effects of cardiopulmonary and metabolic rehabilitation in post-COVID-19 patients: Clinical trial. Journal of Clinical Images and Medical Case Reports. 2023 Nov 2;4(11). 
26.     del Corral T, Fabero-Garrido R, Plaza-Manzano G, Fernández-de-las-Peñas C, Navarro-Santana MJ, López-de-Uralde-Villanueva I. Minimal Clinically Important Differences in Inspiratory Muscle Function Variables after a Respiratory Muscle Training Programme in Individuals with Long-Term Post-COVID-19 Symptoms. J Clin Med. 2023 Apr 5;12(7):2720. 

Additional Files

Published

2025-11-28

How to Cite

1.
Widjanantie SC, Tjawanta EA, Damayanti T, Rumende CM, Putri AP, Agustin H, Setiawati E, Wahyudati S. Correlation between Maximal Inspiratory Pressure and the Sit-to-Stand Test in Post-COVID-19 Patients. Medica Hospitalia J. Clin. Med. [Internet]. 2025 Nov. 28 [cited 2025 Dec. 4];12(3):305-14. Available from: https://medicahospitalia.rskariadi.co.id/index.php/mh/article/view/1382

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