Correlation Hemoglobin and Hematocrit Levels with Total Iron Binding Capacity (TIBC) Levels in Chronic Kidney Disease Patients

Authors

  • Galuh Ajeng Lidyaningrum Department of Medical Laboratory Technology, Faculty of Health Sciences, Universitas Muhammadiyah Sidoarjo, East Java, Indonesia
  • Andika Aliviameita Department of Medical Laboratory Technology, Faculty of Health Sciences, Universitas Muhammadiyah Sidoarjo, East Java, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v13i1.1387

Keywords:

Chronic Kidney Disease, Hemoglobin, Hematocrits, TIBC

Abstract

BACKGROUND : Chronic Kidney Failure (CKD) is a condition where the kidneys are structurally and functionally damaged characterized by a decrease in Glomerular Filtration Rate (GFR) reaching ≤ 60 ml/min/1.73m2 for more than three months. About 80 - 90% of patients with CKD experience anemia.

AIMS : This research aims to determine the correlation of hemoglobin and hematocrit levels with Total Iron Binding Capacity (TIBC) levels in patients with chronic renal failure.

METHOD : The research design used quantitative analysis with cross sectional method. The study used secondary data of as many as 55 respondents of chronic kidney disease patients undergoing hemodialysis. This study was conducted at the East Java Province Haji Hospital in March 2025.

RESULT :  The normality test results showed that hemoglobin and hematocrit levels were not normally distributed (p < 0.05) while TIBC levels were normally distributed (p > 0.05). Kendall's tau b non-parametric correlation test there is no correlation between hemoglobin levels with TIBC (r = 0.134; p = 0.154), and hematocrit with TIBC levels (r = 0.172; p = 0.066).

CONCLUSION : The results of this study showed no correlation between hemoglobin and hematocrit levels with total iron binding capacity (TIBC) levels in chronic kidney disease patients undergoing hemodialysis at Haji Provincial General Hospital of East Java .

Downloads

Download data is not yet available.

References

1.     Falah MH, Setyawati T, Walanda RM, Putrie IR. Hubungan Kadar Kreatinin dengan Hemoglobin pada Pasien Gagal Ginjal Kronik (GGK) di RSUD Undata Provinsi Sulawesi Tengah Tahun 2022. Medika Tadulako [Internet]. 2024;9(1):40–6. Available from: https://jurnal.fk.untad.ac.id/index.php/mtj/article/view/1255/572
2.     Aditama NZ, Kusumajaya H, Fitri N. Faktor-Faktor yang Berhubungan dengan Kualitas Tidur Pasien Gagal Ginjal Kronis. Jurnal Penelitian Perawat Profesional [Internet]. 2023;6(1):109–20. Available from: https://jurnal.globalhealthsciencegroup.com/index.php/JPPP/article/view/1919/1579
3.     Ngara YW, Rosdiana Y, Rahayu W. Harga Diri Dengan Kualitas Hidup Pasien Gagal Ginjal Kronik (GGK) Yang Menjalani Hemodialisa Pada Masa Pandemi Covid-19. Care : Jurnal Ilmiah Ilmu Kesehatan [Internet]. 2022;10(2):304–14. Available from: https://r.search.yahoo.com/_ylt=Awr.zn0Bni1n8eIDUvJXNyoA;_ylu=Y29sbwNncTEEcG9zAzYEdnRpZAMEc2VjA3Ny/RV=2/RE=1732252418/RO=10/RU=https%3A%2F%2Fjurnal.unitri.ac.id%2Findex.php%2Fcare%2Farticle%2Fdownload%2F3627%2Fpdf/RK=2/RS=IYrcTecX08__6ROyCsr5qs4hD18-
4.     Alfonso AA, Mongan AE, Memah MF. Gambaran Kadar Kreatinin Serum pada Pasien Penyakit Ginjal Kronik Stadium 5 Non Dialisis. Jurnal e-Biomedik [Internet]. 2016 Jul 12;4(2):2–7. Available from: https://ejournal.unsrat.ac.id/v3/index.php/ebiomedik/article/view/10862/10450
5.     National Institute of Diabetes and Digestive and Kidney Deases. Hemodialisis [Internet]. niddk.nih.gov. Available from: https://www.niddk.nih.gov/health-information/kidney-disease/kidney-failure/hemodialysis
6.     Heriansyah, Aji Humaedi NW. Gambaran Ureum Dan Kreatinin Pada Pasien Gagal Ginjal Kronis Di Rsud Karawang. Binawan Student Journal. 2019;01(01):8–14. 
7.     Fatresia W, Wulandari M, Alfarisi R, Hidayat. Perbedaan Jumlah Eritrosit Sebelum dan Sesudah Hemodialisa Pada Pasien Laki-laki Dengan Gagal Ginjal Kronik. Jurnal Penelitian Perawat Profesional. 2024;6(6):2373–82. 
8.     Yuniarti W. Anemia pada Pasien Gagal Ginjal Kronik Anemia in Chronic Kidney Disease Patients. Journal Health And Science ; Gorontalo Journal Health & Science Community. 2021;5(2):341–7. 
9.     KEMENKES. Keputusan Menteri Kesehatan RI Tentang Pedomal Tata Laksana Gagal Ginjal Kronik. 2023. p. 1–289. 
10.     Elsayed AS, Azab AE. Correlation between chronic kidney diseases and hematolgical data in sabratha hospital in libya. Asian Journal of Pharmaceutical and Clinical Research. 2017;10(2):291–6. 
11.     Thang LV, Kien NT, Hung N Van, Kien TQ, Dung NH, Huong NTT, et al. Serum total iron-binding capacity and iron status in patients with non-dialysis-dependent chronic kidney disease: A cross-sectional study in Vietnam. Asia Pacific journal of clinical nutrition. 2020;29(1):48–54. 
12.     Ekowati L. Korelasi Antara Kadar Hemoglobin Dengan Total Iron Binding Capacity (TIBC) Pada Penderita Penyakit Ginjal Kronik (PGK) Derajat V Yang Menjalani Hemodialisis Di Rs Toeloengredjo Pare Kediri. Jurnal Insan Cendekia. 2023;10(2):99–105. 
13.     Wayan N, Dewi AM, Gede L, Yenny S, Cahyawati PN. Hubungan Kadar Kreatinin dan Ureum dengan Derajat Anemia pada Pasien Penyakit Ginjal Kronik di RSUD Sanjiwani Gianyar. AMJ (Aesculapius Medical Journal) [Internet]. 2023;3(1):74–80. Available from: https://www.ejournal.warmadewa.ac.id/index.php/amj/article/view/5426
14.     Rahelić V, Perković T, Romić L, Perković P, Klobučar S, Pavić E, et al. The Role of Behavioral Factors on Chronic Diseases—Practice and Knowledge Gaps. Healthcare (Switzerland). 2024;12(24):1–22. 
15.     Johnson RJ, Wesseling C, Newman LS. Chronic Kidney Disease of Unknown Cause in Agricultural Communities. New England Journal of Medicine. 2019;380(19):1843–52. 
16.     Bikbov B, Purcell C, Levey AS, Smith M, Abdoli A, Abebe M, et al. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2020;395(10225):709–33. 
17.     Farahmand M, Ramezani Tehrani F, Khalili D, Cheraghi L, Azizi F. Endogenous estrogen exposure and chronic kidney disease; a 15-year prospective cohort study. BMC Endocrine Disorders. 2021;21(1):1–8. 
18.     Lumbantobing MP. Gambaran Kadar Hemoglobin dan Kadar Kreatinin pada Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisis di RSUD Tarutung. Jurnal Kedokteran Meditek. 2022;28(3):264–8. 
19.     Denic A, Lieske JC, Chakkera HA, Poggio ED, Alexander MP, Singh P, et al. The Substantial Loss of Nephrons in Healthy Human Kidneys with Aging. Journal of the American Society of Nephrology [Internet]. 2016;28(1):313–21. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5198286/
20.     Nuroini F, Wijayanto W. Gambaran Kadar Ureum dan Kreatinin pada Pasien Gagal Ginjal Kronis di RSU Wirdadi Husada. Jambura Journal of Health Sciences and Research. 2022;4(2):538–45. 
21.     Astuti D, Kulsum U. Pola Menstruasi dengan Terjadinya Anemia pada Remaja Putri. Jurnal Ilmu Keperawatan dan Kebidanan. 2020;11(2):314–27. 
22.     Cases A, Egocheaga MI, Tranche S, Pallarés V, Ojeda R, Górriz JL, et al. Anemia of chronic kidney disease: Protocol of study, management and referral to Nephrology. Nefrología (English Edition) [Internet]. 2018;38(1):8–12. Available from: http://dx.doi.org/10.1016/j.nefroe.2018.01.007
23.     Silaban BJ, Sugeng C, Waleleng BJ. Gambaran status besi pada pasien penyakit ginjal kronik stadium 5 dengan anemia yang menjalani hemodialisis reguler. Jurnal e-Clinic. 2016;4(2). 
24.     Devi PR, Arif YW. Kadar Total Iron Binding Capacity (TIBC) Pada Pasien Gagal Ginjal Kronis. Kesehatan Aisyiyah [Internet]. 2020;01. Available from: https://digilib.unisayogya.ac.id/5498/1/RIKA PUSPITA DEVI_1611304047_TLM_NASPUB - Rika Puspita Devi.pdf
25.     Iron Disorders Institute. Anemia Of Chronic Disease [Internet]. Available from: https://irondisorders.org/anemia-of-chronic-disease-2/#:~:text=In adults%2C anemia of chronic,an autoimmune disease is present.
26.     Yu PH, Lin MY, Chiu YW, Lee JJ, Hwang SJ, Hung CC, et al. Low serum iron is associated with anemia in CKD stage 1–4 patients with normal transferrin saturations. Scientific Reports [Internet]. 2021;11(1):1–10. Available from: https://doi.org/10.1038/s41598-021-87401-w
27.     Ulya NF, Kusdinar G, Santoso K. The correlation between creatinine serum with total iron binding capacity (TIBC) on patients with sufferers chronic renal disease in Gambiran regional public hospital Kediri city. Medical Laboratory Analysis and Sciences Journal. 2019;1(1):19–24. 
28.     Arifin Z, Fatmawati BR. Anemia Pada Pasien dengan Gagal Ginjal Kronik yang Menjalani Hemodialisa. Jurnal Prima. 2023;9(2):1–7. 
29.     Helmyati S, Hasanah FC, Putri F, Sundjaya T, Dilantika C. Biochemistry Indicators for the Identification of Iron Deficiency Anemia in Indonesia: A Literature Review. Amerta Nutrition. 2023;7(3):62–70. 
30.     Rahmatullah W, Labito RB, Aini R, Azimata R, Handayani R. The Differences Of Edta And Heparin Anticoagulans On Hematocrit Value. Jurnal Kesehatan Saintika Meditory. 2023;6(1):331–41. 
31.     Eka Safitri D, Woelansari ED, Suhariyadi. Relationship of Red Cell Distribution Width (RDW) To the Results Total Iron Binding Capacity (TIBC) In Chronic Kidney Failure Patients with Anemia. Medicra (Journal of Medical Laboratory Science/Technology). 2022;5(2):109–14. 
32.     Faruqi A, Zubair M. Iron-Binding Capacity - StatPearls - NCBI Bookshelf (1) [Internet]. NCBI; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559119/#__NBK559119_dtls__

Additional Files

Published

2026-04-01

How to Cite

1.
Lidyaningrum GA, Aliviameita A. Correlation Hemoglobin and Hematocrit Levels with Total Iron Binding Capacity (TIBC) Levels in Chronic Kidney Disease Patients. Medica Hospitalia J. Clin. Med. [Internet]. 2026 Apr. 1 [cited 2026 Apr. 2];13(1):10-6. Available from: https://medicahospitalia.rskariadi.co.id/index.php/mh/article/view/1387

Issue

Section

Original Article

Citation Check