Prenatal, Perinatal And Postnatal Risk Factors From Mother And Child To The Incidence Of Epilepsy
DOI:
https://doi.org/10.36408/mhjcm.v11i1.1042Keywords:
Adulthood epilepsy, prenatal, perinatal, postnatal, risk factorsAbstract
BACKGROUND: Epilepsy is a health problem that affects sufferers and their families, characterized by at least two seizures without provocation with an interval of more than 24 hours between seizures, one seizure without provocation with the possibility of recurring within 10 years, a diagnosis of epilepsy syndrome has been established. The risk of epilepsy can be influenced by the condition of the mother and child in the prenatal, perinatal and postnatal periods.
AIMS: This study analyzed the risks of several prenatal, perinatal, and postnatal factors of mother and child as risk factors for epilepsy incidence.
METHOD: A case control study was conducted at RSUP Dr. Kariadi Semarang from July 2022 to March 2023. A total of 90 eligible subjects were divided into 45 case with epilepsy and 45 control with a non-epileptic diagnosis. Inclusion criteria were aged over 17 years to 40 years and exclusion criteria were subjects with mothers who had died or could not be interviewed, data were incomplete and had structural brain disorders or other diseases with clinical symptoms of seizures for the control group. The data obtained were analyzed using chi squares test for bivariate association, followed by multivariate analysis with multiple logistic regression.
RESULT: Maternal age during pregnancy (p=0.016), low birth weight (p=0.007), surgical birth (p=0.004), head trauma at the age of less than 6 years (p=0.008) have been shown to influence the occurrence of epilepsy with significance respectively.
CONCLUSION: Prenatal factors of the mother which is maternal age during pregnancy, perinatal and postnatal factors of the child which are low birth weight, surgical birth, and head trauma at the age of less than 6 years are risk factors that influence the occurrence of adulthood epilepsy.
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References
1. Epilepsi. Edisi ketiga. Yogyakarta. Gadjah Mada University Press; 2021
2. Nomura Y, John RM, Janssen AB, Davey C, Finik J, Buthmann J, et al. Neurodevelopmental consequences in offspring of mothers with preeclampsia during pregnancy: underlying biological mechanism via imprinting genes. Archives of gynecology and obstetrics. 2017;295:1319-29.
3. Webster KM, Sun M, Crack P, O’Brien TJ, Shultz SR, Semple BD. Inflammation in epileptogenesis after traumatic brain injury. Journal of neuroinflammation. 2017;14:1-7.
4. Vezzani A, Balosso S, Ravizza T. Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy. Nature Reviews Neurology. 2019;15(8):459-72.
5. Aninditha T, Wiratman W. Buku ajar neurologi. Jakarta: Penerbit Kedokteran Indonesia; 2017.
6. Sun Y, Vestergaard M, Pedersen CB, Christensen J, Basso O, Olsen J. Gestational age, birth weight, intrauterine growth, and the risk of epilepsy. American journal of epidemiology. 2008;167(3):262-70.
7. Georgieff SE. Preterm Nutrition and the Brain. World Rev Nutr Diet. 2014;110:190-200.
8. Sandström A, Cnattingius S, Wikström AK, Stephansson O. Labour dystocia—risk of recurrence and instrumental delivery in following labour—a population‐based cohort study. BJOG: An International Journal of Obstetrics & Gynaecology. 2012;119(13):1648-56.
9. Ekéus C, Högberg U, Norman M. Vacuum assisted birth and risk for cerebral complications in term newborn infants: a population-based cohort study. BMC pregnancy and childbirth. 2014;14:1-0.
10. Kliegman R, Stanton B, St Geme J, Schor N F, Behrman R. Nelson Texbook of Pediatric. Ed 21. Philadelphia, PA : Elsevier Inc; p. 341-56
11. Tau GZ, Peterson BS. Normal development of brain circuits. Neuropsychopharmacology. 2010;35(1):147-68.
12. Åberg K. Neonatal complications following birth by vacuum extraction. Inst för kvinnors och barns hälsa/Dept of Women's and Children's Health; 2017 Oct 25.
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Copyright (c) 2024 Susan Megawati Sibuea, Endang Kustiowati, Maria Immaculata Widiastuti Samekto, Dodik Tugasworo, Aris Catur Bintoro, Elta Diah Pasmanasari (Author)
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