Peran Fisioterapi pada Myastenia Gravis Paska Tymectomy

Role of Physiotherapy in Patient with Myasthenia Gravis post Thymectomy

Authors

  • I Gede Egy Saputra Jaya Departemen Kedokteran Umum, Bali International Medical Centre Hospital Nusa Dua Bali, Indonesia, Indonesia
  • Kartika Anatasia Kosasih Rumah Sakit Khusus Bedah BIMC Nusa Dua, Bali, Indonesia
  • Anak Agung Ayu Srikandhyawati Karang Departemen Rehabilitasi Medik, Bali International Medical Centre Hospital Bali, Indonesia, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v9i3.599

Keywords:

fisioterapi, myastenia gravis, thymectomy, kelemahan otot

Abstract

LATAR BELAKANG : Myastenia gravis (MG) merupakan penyakit autoimun yang disebabkan akibat timbulnya antibody terhadap reseptor asetilkolin esterase (AChR) pada neuromuscular junction yang menimbulkan kelemahan otot okular, bulbar, respirasi, aksial dan ekstremitas. Berdasarkan rekomendasi, rehabilitasi memiliki peran penting dalam pencegahan dari komplikasi MG seperti kontraktur dan kegagalan pernapasan. Namun, pada MG akan terjadi kelemahan otot dengan latihan fisis dan penggunaan otot secara repetitive yang menyebabkan dokter menjadi ragu untuk merekomendasikan rehabilitasi medik pada pasien MG. Tujuan dari laporan kasus ini adalah untuk mengetahui peran rehabilitasi medik pada pasien MG.

PRESENTASI KASUS : Pasien laki-laki 20 tahun dengan MG paska operasi video-assisted thoracoscopic surgery (VATS) thymectomy. Operasi berjalan lancar dan program rehabilitasi dilakukan pada hari kedua perawatan dengan supervisi dokter rehabilitasi medik dengan program: latihan pernapasan, latihan peregangan anggota gerak, dan relaksasi selama 30 menit pagi hari. Pada hari ke-3 pasien mengalami perburukan klinis sehingga terpasang ventilator mekanik. Pada hari berikutnya kondisi pasien membaik dan program rehabilitasi dilanjutkan setelah kesadaran pasien membaik sebanyak  2x dalam sehari dengan durasi 30-60 menit. Kondisi pasien berangsur membaik  dan pada hari ke-10 pasien dipulangkan dengan bantuan oksigenasi ResMed.

PEMBAHASAN: Pada pasien dengan MG generalisata dan gangguan sistem respirasi, pelatihan otot respirasi terbukti efektif untuk menangani kelemahan otot akibat fatigue atau kegagalan pernasasan. Manfaat dari latihan pernapasan tidak hanya berupa peningkatan kekuatan otot respirasi, ketahanan pernapasan dan performa fisis, namun juga penurunan dari beberapa komplikasi MG dan meningkatkan kualitas hidup pasien. Pada pasien MG paska operasi, latihan dapat dengan aman dilakukan segera setelah terekstubasi dengan supervisi dokter rehabilitasi medik.

SIMPULAN: Fisioterapi bermanfaat pada pasien MG paska thymectomy. Program rehabilitasi medik sebaiknya dirancang sesuai dengan kondisi pasien MG dan dilakukan dalam supervisi dokter rehabilitasi medik.

KATA KUNCI: fisioterapi, myastenia gravis, thymectomy, kelemahan otot

Downloads

Download data is not yet available.

References

Hehir MK, Silvestri NJ. Generalized Myasthenia Gravis: Classification, Clinical Presentation, Natural History, and Epidemiology. Neurol Clin. 2018 May 1;36(2):253–60.

Dalakas MC. Immunotherapy in myasthenia gravis in the era of biologics. Nat Rev Neurol. 2019;15(2):113–24.

Naumes J, Hafer Macko C. Exercise and Myasthenia Gravis: A Review of the Literature to Promote Safety, Engagement and Functioning. Int J Neurorehabilitation. 2016;3(3).

Narayanaswami P, Sanders DB, Wolfe G, Benatar M, Cea G, Evoli A, et al. International Consensus Guidance for Management of Myasthenia Gravis. Neurology. 2021 Jan;96(3):114 LP – 122.

Corrado B, Giardulli B, Costa M. Evidence-based practice in rehabilitation of myasthenia gravis. A systematic review of the literature. J Funct Morphol Kinesiol. 2020;5(4).

Jayam Trouth A, Dabi A, Solieman N, Kurukumbi M, Kalyanam J. Myasthenia gravis: a review. Betterle C, editor. Autoimmune Dis. 2012;2012:874680.

Kwiatkowska K, Lamtych M, Kubiak K, Badiuk N. Physiotherapy in myasthenia gravis. J Educ Heal Sport. 2018;8(12):1027–38.

O’Connor L, Westerberg E, Punga AR. Myasthenia gravis and physical exercise: a novel paradigm. Front Neurol. 2020;11:675.

Bach JR. Noninvasive respiratory management of patients with neuromuscular disease. Ann Rehabil Med. 2017;41(4):519–38.

Farrugia ME, Goodfellow JA. A Practical Approach to Managing Patients With Myasthenia Gravis—Opinions and a Review of the Literature. Front Neurol. 2020;11(July):1–16.

Voulgaris A, Antoniadou M, Agrafiotis M, Steiropoulos P. Respiratory involvement in patients with neuromuscular diseases: a narrative review. Dal Negro RW, editor. Pulm Med. 2019;2019:2734054.

Van Hollebeke M, Poddighe D, Clerckx B, Muller J, Hermans G, Gosselink R, et al. High-Intensity Inspiratory Muscle Training Improves Scalene and Sternocleidomastoid Muscle Oxygenation Parameters in Patients With Weaning Difficulties: A Randomized Controlled Trial [Internet]. Vol. 13, Frontiers in Physiology . 2022. Available from: https://www.frontiersin.org/article/10.3389/fphys.2022.786575

Vorona S, Sabatini U, Al-Maqbali S, Bertoni M, Dres M, Bissett B, et al. Inspiratory muscle rehabilitation in critically ill adults a systematic review and meta-analysis. Ann Am Thorac Soc. 2018;15(6):735–44.

Bissett BM, Leditschke IA, Neeman T, Boots R, Paratz J. Inspiratory muscle training to enhance recovery from mechanical ventilation: a randomised trial. Thorax. 2016;71(9):812 LP – 819.

Bissett B, Leditschke IA, Green M, Marzano V, Collins S, Van Haren F. Inspiratory muscle training for intensive care patients: A multidisciplinary practical guide for clinicians. Aust Crit Care. 2019;32(3):249–55.

Evans JA, Whitelaw WA. The Assessment of Maximal Respiratory Mouth Pressures In Adults. Respir Care. 2009;54(10):1348–59.

Rassler B, Marx G, Hallebach S, Kalischewski P, Baumann I. Long-term respiratory muscle endurance training in patients with myasthenia gravis: First results after four months of training. Autoimmune Dis. 2011;1(1).

Freitag S, Hallebach S, Baumann I, Kalischewski P, Rassler B. Effects of long-term respiratory muscle endurance training on respiratory and functional outcomes in patients with Myasthenia gravis. Respir Med. 2018;144:7–15.

Aslan GK, Nilgun Gurses H, Issever H, Kiyan E. Effects of respiratory muscle training on pulmonary functions in patients with slowly progressive neuromuscular disease: A randomized controlled trial. Clin Rehabil. 2014;28(6):573–81.

Sklar MC, Dres M, Fan E, Rubenfeld GD, Scales DC, Herridge MS, et al. Association of low baseline diaphragm muscle mass with prolonged mechanical ventilation and mortality among critically ill adults. JAMA Netw Open. 2020 Feb 19;3(2):e1921520–e1921520.

Boitano LJ. Management of Airway Clearance in Neuromuscular Disease Introduction Cough Physiology and Mechanics Pathophysiology of Neuromuscular Impaired Cough Evaluation of Cough Impairment Indications for Cough-Augmentation Therapy Cough-Augmentation Therapies Manu. Respir Care. 2006;51(8):913–22.

Benditt JO. Respiratory Care of Patients With Neuromuscular Disease. Respir Care. 2019;64(6):679–88.

Choong K, Canci F, Clark H, Hopkins R, Kudchadkar S, Lati J, et al. Practice recommendations for early mobilization in critically ill children. J Pediatr Intensive Care. 2018;07(01):014–26.

Ambrosino N, Venturelli E, Vagheggini G, Clini E. Rehabilitation, weaning and physical therapy strategies in chronic critically ill patients. Eur Respir J. 2012;39(2):487–92.

Polastri M, Stella F, Lambertini M, Trani W, Ghetti A, Dell’Amore A. Physiotherapy immediately after thymectomy in patients with myasthenia gravis. Ann Ital cHIR. 2017;88(2):105–9.

Ambrogi V, Mineo TC. Benefits of Comprehensive Rehabilitation Therapy in Thymectomy for Myasthenia Gravis: A Propensity Score Matching Analysis. Am J Phys Med Rehabil. 2017;96(2):77–83.

Aboussouan LS. Mechanisms of exercise limitation and pulmonary rehabilitation for patients with neuromuscular disease. Chron Respir Dis. 2009;6(4):231–49.

Cup EH, Pieterse AJ, ten Broek-Pastoor JM, Munneke M, van Engelen BG, Hendricks HT, et al. Exercise therapy and other types of physical therapy for patients With neuromuscular diseases: a systematic review. Arch Phys Med Rehabil. 2007;88(11):1452–64.

Fregonezi GA de F, Resqueti VR, Güell R, Pradas J, Casan P. Effects of 8-week, interval-based inspiratory muscle training and breathing retraining in patients with generalized myasthenia gravis. Chest. 2005;128(3):1524–30.

Additional Files

Published

2022-11-30

How to Cite

1.
Jaya IGES, Anatasia Kosasih K, Karang AAAS. Peran Fisioterapi pada Myastenia Gravis Paska Tymectomy: Role of Physiotherapy in Patient with Myasthenia Gravis post Thymectomy. Medica Hospitalia J. Clin. Med. [Internet]. 2022 Nov. 30 [cited 2024 Dec. 22];9(3):383-8. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/599

Citation Check