Serial Case: Infarct Stroke In Covid 19 Patients

Authors

  • Retnaningsih Retnaningsih Department of Neurology Faculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, Indonesia, Indonesia
  • Fatiha Sri Utami Tamad Neurology Department, Jenderal Soedirman University Purwokerto , Indonesia
  • Dodik Tugasworo Department of Neurology Faculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, Indonesia, Indonesia
  • Yovita Andhitara Department of Neurology Faculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, Indonesia, Indonesia
  • Rahmi Ardhini Department of Neurology Faculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, Indonesia, Indonesia
  • Aditya Kurnianto Department of Neurology Faculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, Indonesia, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v10i1.744

Keywords:

Stroke infarction, COVID 19, SARS-CoV-2, Hypercoagulation, Vasculopathy

Abstract

Introduction: SARS-CoV-2 has been reported to cause various neurological symptoms including stroke. SARS-CoV-2 infection causes the release of cytokines, proinflammatory chemokines, immune system activation, coagulopathy, endothelium, vasculitis, hypoxia, renin-angiotensin system imbalance, and cardiovascular complications, all of which can contribute to stroke.

Purpose: Describe the incidence of stroke with different conditions in COVID 19

Cases: There were two cases of stroke infarct in a COVID-19 patient who was admitted to our hospital. Both were treated with a diagnosis of stroke infarct with previous COVID-19 symptoms, the results of laboratory examinations revealed an increase in inflammatory markers in both patients and had been given appropriate treatment according to each patient's condition. But at the end of the treatment one patient died and the other patient went home with clinical improvement.

Discussion: The incidence of stroke infarct in this case is thought to be due to several factors, namely the presence of comorbidities in the patient, microvascular thrombus due to the formation of neutrophil extracellular traps (NET), activation of complement which causes thrombogenesis and vasculopathy, formation of antiphospholipid antibodies so that protein c is reduced, the formation of microparticles causes platelet hyperactivation. and increased tissue factor (TF) resulting in hypercoagulation. Adequate therapy in controlling inflammation due to COVID 19 has shown clinical improvement in stroke infarct patients.

Conclusion: There are 2 cases of stroke infarction in patients with covid 19 who have comorbidities. The first case with COVID advanced stages experienced a worsening of the condition despite being given appropriate therapy. The second case with COVID middle stages experienced an improvement in the condition after the viral inflammatory factors were controlled and the comorbidity was well controlled.

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Additional Files

Published

2023-03-31

How to Cite

1.
Retnaningsih R, Tamad FSU, Tugasworo D, Andhitara Y, Ardhini R, Kurnianto A. Serial Case: Infarct Stroke In Covid 19 Patients. Medica Hospitalia J. Clin. Med. [Internet]. 2023 Mar. 31 [cited 2024 May 3];10(1):124-8. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/744

Issue

Vol. 10 No. 1 (2023): Med Hosp; March 2023

Section

Case Report

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