Predictor Factors of Tuberculosis Treatment Success in Sleman Regency of Indonesia

Predictor Factors of Tuberculosis Treatment Success in Sleman Regency of Indonesia

Authors

  • Eko Andriyanto Master Program in Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University/ Department of Microbiology Faculty Of Medicine Universitas Islam Indonesia Yogyakarta, Indonesia
  • Yanri Wijayanti Subronto Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University / Dokter Sardjito General Hospital, Yogyakarta, Indonesia
  • Ida Safitri Laksanawati

DOI:

https://doi.org/10.36408/mhjcm.v9i2.756

Keywords:

Predictors, Treatment success, Tuberculosis

Abstract

Background : Tuberculosis (TB) is the leading cause of mortality worldwide. Several studies have created risk scores to predict treatment success in TB patients. However, cohort study did not consider other clinical forms of TB, such as negative AFB smears and extrapulmonary TB. The objectives of this study was to knowing the predictor factors for the success of TB treatment in Sleman Regency by taking into account other  clinical forms of TB such as negative smear and extrapulmonary TB.

Methods : The type and design of this study was an analytical study using a cross- sectional design conducted on TB patients in Sleman Regency from 2015 – 2018. Data were collected from TB 01 or TB 03 register of the Sleman District Health Office, including age, sex, BMI at the beginning of treatment, OAT (Antituberculosis Drugs) guideline, anatomic location, initial AFB status, AFB conversion status in intensive phase, type of TB patient, and treatment outcome. Chi-Square analysis and logistic regression were used to  determine the predictors of TB treatment success.

Results : The research sample was 2308 people: 2158 successful treatments and 150 patients whofailed. AFB conversion in the intensive phase was the only variable to have a role in the TB treatment success (OR = 6.655, 95% CI: 3.354–13,207, p = 0.000).

Conclusion : Conversion of AFB status in the intensive phase is a variable that contributes to the success of TB treatment. Age, sex, BMI at the beginning of treatment, OAT guidelines, anatomic location, initial AFB status, and type of TB patient are not predictors of TB success.

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References

World Health Organization. Global Tuberculosis Report 2021. Glob Tuberc Rep. 2021;1–57.

Rojano B, Caminero JA, Hayek M. Curving Tuberculosis: Current Trends and Future Needs. Ann Glob Heal. 2019;85(1).

Abouzeid MS, Al Hakeem RF, Memish ZA. Mortality among tuberculosis patients in Saudi Arabia (2001–2010). Ann Saudi Med. 2013;33(3):247–52.

Bhargava A, Chatterjee M, Jain Y, Chatterjee B, Kataria A, Bhargava M, et al. Nutritional status of adult patients with pulmonary tuberculosis in rural central India and its association with mortality. PLoS One. 2013;8(10).

Choi H, Yoo JE, Han K, Choi W, Rhee SY, Lee H, et al. Body Mass Index, Diabetes, and Risk of Tuberculosis: A Retrospective Cohort Study. Front Nutr. 2021;8.

Pefura-Yone EW, Balkissou AD, Poka-Mayap V, Fatime- Abaicho HK, Enono-Edende PT, Kengne AP. Development and validation of a prognostic score during tuberculosis treatment. BMC Infect Dis. 2017;17(1):1–9.

Horita N, Miyazawa N, Yoshiyama T, Sato T, Yamamoto M, Tomaru K, et al. Development and validation of a tuberculosis prognostic score for smear-positive in-patients in Japan. INT J TUBERC LUNG DIS. 2013;17(1):54–60.

Ambreen A, Jamil M, Rahman MAU, Mustafa T. Viable Mycobacterium tuberculosis in sputum after pulmonary tuberculosis cure. BMC Infect Dis. 2019;19(1):923.

Chadha VK, Kumar P, Anjinappa SM, Singh S, Narasimhaiah S, Joshi M V., et al. Prevalence of pulmonary tuberculosis among adults in a rural sub-district of South India. PLoS One. 2012;7(8).

Gebrezgabiher G, Romha G, Ejeta E, Asebe G, Zemene E, Ameni

G. Treatment Outcome of Tuberculosis Patients under Directly Observed Treatment Short Course and Factors Affecting Outcome in Southern Ethiopia: A Five-Year Retrospective Study. PLoS One. 2016;11(2).

Alobu I, Oshi DC, Oshi SN, Ukwaja KN. Profile and determinants of treatment failure among smear-positive pulmonary tuberculosis patients in Ebonyi, Southeastern Nigeria. Int J mycobacteriology. 2014;3(2):127–31.

Berhe G, Enquselassie F, Aseffa A. Treatment outcome of smear-positive pulmonary tuberculosis patients in Tigray Region, Northern Ethiopia. BMC Public Health. 2012 Jul 23;12(1):1–9.

Shibabaw A, Gelaw B, Wang S-H, Tessema B. Time to sputum smear and culture conversions in multidrug resistant tuberculosis at University of Gondar Hospital, Northwest Ethiopia. PLoS One. 2018;13(6):e0198080.

Tachfouti N, Slama K, Berraho M, Elfakir S, Benjelloun MC, El Rhazi KE, et al. Determinants of Tuberculosis treatment default in Morocco: Results from a National Cohort Study. Pan Afr Med J. 2013;14.

Yen YF, Chuang PH, Yen MY, Lin SY, Chuang P, Yuan MJ, et al. Association of body mass index with tuberculosis mortality: A population-based follow-up study. Med (United States). 2 0 1 6 ; 9 5 ( 1 ) . j o u r n a l / F u l l t e x t / 2 0 1 6 / 0 1 0 5 0 / Association_of_Body_Mass_Index_With_Tuberculosis.15.asp x

Choi H, Lee M, Chen RY, Kim Y, Yoon S, Joh JS, et al. Predictors of pulmonary tuberculosis treatment outcomes in South Korea: A prospective cohort study, 2005-2012. BMC Infect Dis. 2014;14(1):1–12.

Cegielski JP, Arab L, Cornoni-Huntley J. Nutritional risk factors for tuberculosis among adults in the United States, 1971–1992. Am J Epidemiol. 2012;176(5):409–22.

Finlay A, Lancaster J, Holtz TH, Weyer K, Miranda A, Van Der Walt M. Patient- and provider-level risk factors associated with default from tuberculosis treatment, South Africa, 2002: A case- control study. BMC Public Health. 2012;12(1):1–12.

Additional Files

Published

2022-07-30

How to Cite

1.
Andriyanto E, Wijayanti Subronto Y, Ida Safitri Laksanawati. Predictor Factors of Tuberculosis Treatment Success in Sleman Regency of Indonesia: Predictor Factors of Tuberculosis Treatment Success in Sleman Regency of Indonesia. Medica Hospitalia J. Clin. Med. [Internet]. 2022 Jul. 30 [cited 2024 Jul. 20];9(2):187-93. Available from: https://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/756

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