Mean Platelet-Lymphocyte Volume Ratio as Predictors of Coronary Artery Severity in Chronic Coronary Syndrome

Authors

  • Friska Wijaya Department of Medicine, Faculty of Medicine, Diponegoro University, Semarang, Indonesia, Indonesia
  • Charles Limantoro Division of Cardiology, Departement of Internal Medicine, Faculty of Medicine Diponegoro University – dr. Kariadi Hospital, Semarang, Indonesia, Indonesia
  • Indah Fitria Department of Internal Medicine, Faculty of Medicine Diponegoro University – dr. Kariadi Hospital, Semarang, Indonesia, Indonesia
  • Catharina Suharti Division of Hematology and Oncology Medic, Departement of Internal Medicine, Faculty of Medicine Diponegoro University – dr. Kariadi Hospital, Semarang, Indonesia, Indonesia
  • Trilaksana Nugroho Departement of Ophtamology, Faculty of Medicine Diponegoro University – dr. Kariadi Hospital, Semarang, Indonesia, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v10i1.813

Keywords:

Chronic Coronary Syndrome, ChroGensini Score, Mean Platelet Volume, Mean Platelet Volume to Lymphocyte Ratio, Platelet Lymphocyte Ratio.

Abstract

BACKGROUND: The increase in platelet aggregation and inflammation play an essential role in atherosclerosis. Furthermore, the level of activity depends on their size, with larger platelets facilitating the thrombosis process. Severe Coronary Artery Disease (CAD) is associated with low lymphocyte count. It is also linked with Mean platelet volume [MPV], Platelet Lymphocyte Ratio [PLR], and Mean Platelet Volume to Lymphocyte Ratio [MPVLR].

OBJECTIVE:  This study aims to investigate MPV, PLR, and MPVLR as predictors of the severity of Coronary Artery Lesion in Chronic Coronary Syndrome (CCS) using the Gensini score.

METHOD: This is a cross sectional study conducted in Dr. Kariadi General Hospital, involving a total sample of 68 respondents. Furthermore, CCS were evaluated before conducting coronary angiography. The study comprises of two group of patients divided according to their Gensini scores, namely mild and severe, for ≤ 20 and > 20, respectively. MPV, PLR, and MPVLR were then compared between the two groups.

RESULT: At a cut-off level of 3.4, MPVLR predicted the coronary artery severity with a sensitivity, specificity, positive predictive value (PPV), and negative predictive value of 80%, 50%, 82%, and 47% (area under the curve [AUC] 0.67; 95% confidence interval [CI], 0.52-0.82; p 0.029). Meanwhile, its value ≥3.4 has OR 1.55; 95% CI, 0.99-2.43; p 0.034.

CONCLUSION: This study conclude that MPVLR ≥3.4 can be used as a predictor of Coronary Artery Lesion Severity based on the Gensini score in CCS cases.

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Additional Files

Published

2023-03-31

How to Cite

1.
Wijaya F, Limantoro C, Fitria I, Suharti C, Nugroho T. Mean Platelet-Lymphocyte Volume Ratio as Predictors of Coronary Artery Severity in Chronic Coronary Syndrome. Medica Hospitalia J. Clin. Med. [Internet]. 2023 Mar. 31 [cited 2024 May 3];10(1):16-25. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/813

Issue

Vol. 10 No. 1 (2023): Med Hosp; March 2023

Section

Original Article

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