Analgesic Potency Of Ibuprofen, Paracetamol, And Mephenamic Acid: A Randomized Controlled Trial
DOI:
https://doi.org/10.36408/mhjcm.v10i2.842Keywords:
Analgesic, Parasetamol, Ibuprofen, Mefenamic AcidAbstract
BACKGROUND: Analgesics are a group of drugs to relieve pain. The use of analgesics is quite high, around 22.8% is used per year. Selection of analgesic drugs having adequate potency and minimal side effects is needed. Common analgesics publicly known involve paracetamol 500 mg, mefenamic acid 500 mg, and ibuprofen 400 mg. This study aims to compare the analgesic potency of paracetamol 600 mg, ibuprofen 600 mg and mefenamic acid 500 mg.
METHODS: This study used a double blind randomized control trial. The study population was healthy subjects. The study sample consisted of 30 subjects with the inclusion criteria involve normal vital signs, while the exclusion criteria involve history of allergy to NSAID class drugs. This study consisted of three groups namely group 1 (K1)= paracetamol 600 mg, group 2 (K2)= mefenamic acid 500 mg, group 3 (K3)= ibuprofen 600 mg. Each subject was given medication according to the group and their pain latency (the time of onset of constant and unbearable pain) was measured every 30 minutes
RESULTS: The repeated ANOVA test shows P= 0.1507 meaning that no significantly different analgesic potency was found between groups.
CONCLUSION: Paracetamol 600 mg, mefenamic acid 500 mg and ibuprofen 600 mg have equal analgesic potency.
Downloads
References
1. Craig Stevens, George Brenner. opioid analgesics and antagonists- brenner and stevens pharmacology. In: Fifth. 2017. p. 261–71.
2. P Freddy Wilmana. Analgesik - antipiretik analgesik antiinflamasi non steroid dan obat pirai [Analgesics - non-steroidal antipyretic anti-inflammatory analgesics and gout medications]. In: [Pharmacology and therapy]. 4th ed. 1995. p. 207–22.
3. Wick EC, Grant MC, Wu CL. Postoperative multimodal analgesia pain management with nonopioid analgesics and techniques. JAMA Surg. 2017 Jul 1;152(7):691.
4. Garnadi J, Rahmat S, Nv S, Tinggi S, Bandung F, Soekarno J, et al. Formulasi dan evaluasi sediaan [Formulation and evaluation of preparations]. Vol. 2, Journal of Pharmacopolium. 2019.
5. Bakarbessy WHA, Wullur AC, Lolo WA. Uji efek analgesik ekstrak etanol daun sukun (artocarpus altilis) pada tikus putih galur wistar (rattus norvegicus) [Test of analgesic effect of ethanol extract of breadfruit leaves (Artocarpus altilis) on white rats (Rattus norvegicus)]. Vol. 5, Pharmacon Jurnal Ilmiah Farmasi-Unsrat. 2016.
6. Ade Karina M. Pengembangan dan validasi metode KLT-densitometri untuk analisis secara simultan parasetamol, asam mefenamat dan ibuprofen dalam jamu pegel linu [The development and validation of TLC-densitometry method for simultaneous analysis of paracetamol, mefenamic acid and ibuprofen in herbal medicine of Pegel Linu. Jurnal Sains Farmasi & Klinis [Internet]. 2016;2(2):150–61. Available from: http://jsfkonline.org
7. Cajaraville JP. Ibuprofen arginate for rapid-onset pain relief in daily practice: A review of its use in different pain conditions. J Pain Res. 2021 Jan;Volume 14:117–26.
8. Ong CKS, Lirk P, Tan CH, Seymour RA. An evidence-based update on nonsteroidal anti-inflammatory drugs. Clin Med Res. 2007 Mar 1;5(1):19–34.
9. Soleha M, Isnawati A, Fitri N, Adelina R, Soblia HT, Winarsih W. Profil Penggunaan Obat Antiinflamasi Nonstreoid di Indonesia [The profile of the use of nonsteroidal anti-inflammatory drugs in Indonesia]. Jurnal Kefarmasian Indonesia. 2018 Oct 16;109–17.
10. da Silva Dal Pizzol T, Turmina Fontanella A, Cardoso Ferreira MB, Dâmaso Bertoldi A, Boff Borges R, Serrate Mengue S. Analgesic use among the Brazilian population: Results from the National Survey on Access, Use and promotion of rational use of medicines (PNAUM). PLoS One. 2019 Mar 21;14(3):e0214329.
11. Badan Penelitian dan Pengembangan Kesehatan Kementerian RI. Riset Kesehatan Dasar [Basic health research] (Riskesdas). Diakses: 03 Maret 2021, dari http://www.depkes.go.id/resources/download/general/Hasil%20Riskesdas%20 2013.pdf. 2013.
12. Farkouh A, Hemetsberger M, Noe CR, Baumgärtel C. Interpreting the benefit and risk data in between-drug comparisons: Illustration of the challenges using the example of mefenamic acid versus ibuprofen. Pharmaceutics. 2022 Oct 20;14(10).
13. Persatuan Ahli Penyakit Dalam Indonesia (PAPDI). Rekomendasi Penggunaan OAINS [Recommendation of the use of NSAIDs]. 2014th ed.
14. Farhan N, Syamsi N, Sofyan A, Nayoan CR. Swamedikasi obat analgetik untuk mengatasi nyeri pada masyarakat Kawatuna, Kecamatan Palu Selatan Kota Palu [Self-medication of analgesics to treat pain in the people of Kabeluna, South Palu District, Palu City]. Jurnal Medical Profession (Medpro) [Internet]. 2022 [cited 2023 May 29];4(3):212–6. Available from: https://jurnal.fk.untad.ac.id/index.php/medpro/article/view/773
15. Ali A, Maulina Z, al Fath R, Zainsa Asfar M. Perbandingan visual analogue scale antara pemberian analgetik asam mefenamat, paracetamol dan ibuprofen peroral sebelum sirkumsisi [Comparison of visual analogue scale between the administration of mefenamic acid, paracetamol and oral ibuprofen before circumcision]. 2019;6.
16. Henry D, Lim LLY, Garcia Rodriguez LA, Perez Gutthann S, Carson JL, Griffin M, et al. Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: Results of a collaborative meta-analysis. Br Med J. 1996;312(7046):1563–6.
17. Jannah R M. Analisis kuantitatif penggunaan analgesik di puskesmas Cangkringan tahun 2017-2019 dengan metode ATC:DDD dan du 90%. 2020.
18. Lameng F X, Ichsan F, Rui E. Evaluasi pola pengobatan pada pasien osteoarthritis di poli rawat jalan RSUD DR. TC Hillers Maumere periode Januari-Desember 2019 [Evaluation of treatment patterns in osteoarthritis patients at the outpatient clinic of RSUD DR. TC Hillers Maumere for the January-December 2019 period]. Jurnal Akademi Farmasi St Fransiskus Xaverius. 2020;
Additional Files
Published
How to Cite
Issue
Section
Citation Check
License
Copyright (c) 2023 Christin Rony Nayoan, Nur Syamsi
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Copyrights Notice
Copyrights:
Researchers publishing manuscrips at Medica Hospitalis: Journal of Clinical Medicine agree with regulations as follow:
Copyrights of each article belong to researchers, and it is likewise the patent rights
Researchers admit that Medica Hospitalia: Journal of Clinical Medicine has the right of first publication
Researchers may submit manuscripts separately, manage non exclusive distribution of published manuscripts into other versions (such as: being sent to researchers’ institutional repository, publication in the books, etc), admitting that manuscripts have been firstly published at Medica Hospitalia: Journal of Clinical Medicine
License:
Medica Hospitalia: Journal of Clinical Medicine is disseminated based on provisions of Creative Common Attribution-Share Alike 4.0 Internasional It allows individuals to duplicate and disseminate manuscripts in any formats, to alter, compose and make derivatives of manuscripts for any purpose. You are not allowed to use manuscripts for commercial purposes. You should properly acknowledge, reference links, and state that alterations have been made. You can do so in proper ways, but it does not hint that the licensors support you or your usage.
