Relationship Between Serum Albumin Levels And Pulmonary Edema In Glomerulonephritis Patients
DOI:
https://doi.org/10.36408/mhjcm.v10i2.892Keywords:
Chest X-Ray, glomerulonephritis, serum albumin, pulmonary edemaAbstract
Background: Glomerulonephritis is an inflammatory disease of the glomerulus that causes changes in permeability, changes in kidney’s structure, and function of the glomerulus. Hypoalbuminemia in glomerulonephritis can decrease oncotic pressure resulting in extravasation of fluid into the interstitium. In severe hypoalbuminemia, extravasation of fluid can result in pulmonary edema. The subjective of this study was to analyze the correlation between serum albumin and the incidence of pulmonary edema by chest x-ray in patients with glomerulonephritis.
Methods: The samples of this study were collected by purposive sampling using secondary data from the medical records of Dr. Kariadi Hospital in Semarang with a total of 46 subjects from January 2016-January 2021. The serum albumin was categorized as normal if serum albumin was >3,5 g/dL, mild hypoalbuminemia if serum albumin was 2.5-3.5 g/dL and severe hypoalbuminemia if serum albumin was <2.5 g/dL.
Result: Mann Whitney test showed a significant relationship between between serum albumin and the incidence of pulmonary edema by chest x-ray in patients with glomerulonephritis (p = 0.016). A higher mean rank was found in patients with pulmonary edema compared to patients without pulmonary edema.
Conclusion:There is a significant relationship between serum albumin and the incidence of pulmonary edema by chest x-ray in patients with glomerulonephritis. Patients with lower serum albumin have a greater tendency to develop pulmonary edema than patients with higher serum albumin.
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References
1. Satoskar AA, Parikh SV, Nadasdy T. Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis. Nat Rev Nephrol [Internet]. 2020 [cited 2021 Jan 31] ;16(1):32–50. Available from: http://dx.doi.org/10.1038/s41581-019-0178-8
2. Perinandika T, Rachmadi D, Dwiyatnaningrum F. A Study of Hypoalbuminemia and Pleural Effusionin Pediatric Nephrotic Syndrome. Althea Med J. 2017;4(2):188–91.
3. Downie ML, Gallibois C, Parekh RS, Noone DG. Nephrotic syndrome in infants and children: Pathophysiology and management. Paediatr Int Child Health [Internet]. 2017 [cited 2021 Feb 3];37(4):248–58. Available from: http://doi.org/10.1080/20469047.2017.1374003
4. PERNEFRI. 11th Report Of Indonesian Renal Registry 2018. Irr [Internet]. 2018 [cited 2021 Jan 31];1–46. Available from: https://www.indonesianrenalregistry.org/data/IRR 2018.pdf
5. Gupta S, Pepper RJ, Ashman N, Walsh SB. Nephrotic syndrome: Oedema formation and its treatment with diuretics. Front Physiol. 2019;10(JAN):1–10.
6. Hizon MAP, LIM RS, Tan ZK, Yeo SC, Villanueva ART, Liew A. Sun-014 Epidemiology of Glomerulonephritis in Southeast Asia: the Gn-Special (Glomerulonephritis – Singapore- Philippines Epidemiology Cohorts in Adults) Study. Kidney Int Reports [Internet]. 2019 [cited 2021 Mar 24] ;4(7):S158. Available from: https://doi.org/10.1016/j.ekir.2019.05.408
7. Yusria R. Diagnosis Dan Manajemen Glomerulonefritis Kronik. J Kedokt Muhammadiyah Surakarta. 2016;259–72.
8. Akirov A, Masri-Iraqi H, Atamna A, Shimon I. Low Albumin Levels Are Associated with Mortality Risk in Hospitalized Patients. Am J Med [Internet]. 2017;130(12):1465.e11- 1465.e19. Available from: https://doi.org/10.1016/j.amjmed.2017.07.020
9. Pardede SO, Trihono PP, Tambunan T. Gambaran Klinis Glomerulonefritis Akut pada Anak di Departemen Ilmu Kesehatan Anak Rumah Sakit Cipto Mangunkusumo, Jakarta. Sari Pediatr. 2016;6(4):144.
10. Woodcock TE. Plasma volume, tissue oedema, and the steady-state Starling principle. BJA Educ [Internet]. 2017 [cited 2021 Jan 31];17(2):74–8. Available from: http://dx.doi.org/10.1093/bjaed/mkw035
11. Salah I, Hassan A, Ghalib MB. of Kidney Diseases and Transplantation Editorial Lung Disease in Relation to Kidney Diseases Pulmonary edema in the setting of renal. 2005;16(3):282–7.
12. Polito C, Martin GS. Albumin: Physiologic and clinical effects on lung function. Minerva Anestesiol. 2013;79(10):1180–6.
13. Li F, Yuan MZ, Wang L, Wang XF, Liu GW. Characteristics and prognosis of pulmonary infection in patients with neurologic disease and hypoproteinemia. Expert Rev Anti Infect Ther. 2015;13(4):521–6.
14. Bassoli C, Oreni L, Ballone E, Foschi A, Perotti A, Mainini A, et al. Role of serum albumin and proteinuria in patients with SARS-CoV-2 pneumonia. Int J Clin Pract. 2021;75(4):1–5.
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