Breast Cancer Metastases Based on Molecular Subtypes at RSUD Dr. H. Abdul Moeloek Lampung

Authors

  • Nurmayeni Department of Obstetrics and Gynecology, Faculty of Medicine, University of Lampung, Bandar Lampung, Indonesia, Indonesia
  • Nurul Islamy Department of Obstetrics and Gynecology, Faculty of Medicine, University of Lampung, Bandar Lampung, Indonesia, Indonesia
  • Agustyas Tjiptaningrum Clinical Pathology Department, Faculty of Medicine, University of Lampung, Bandar Lampung, Indonesia, Indonesia
  • Bintang Abadi Siregar Department of Surgery, Faculty of Medicine, University of Lampung/RSUD Dr. H. Abdul Moeloek Bandar Lampung, Indonesia, Indonesia
  • Aditya Kusumaningtyas Department of Surgery, Faculty of Medicine, University of Lampung/RSUD Dr. H. Abdul Moeloek Bandar Lampung, Indonesia, Indonesia
  • Indri Windarti Fakultas Kedokteran Unila, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v10i3.904

Keywords:

breast cancer, molecular subtypes, metastases

Abstract

BACKGROUND:Breast cancer is the most common cancer in Indonesia and is a leading cause of cancer-related deaths in the country. Metastases are responsible for most deaths among breast cancer patients. Breast cancer is typically classified into four subtypes based on immunohistochemistry: luminal A, luminal B, HER2+, and TNBC.

OBJECTIVE:To determine the association between the metastatic pattern of breast cancer and their molecular subtypes at RSUD Dr. H. Abdul Moeloek Lampung.

METHOD:This study was an observational analytic study with a cross-sectional design. The sample comprised 81 individuals who had suffered from breast cancer and were recorded in the medical records section of RSUD Dr. H. Abdul Moeloek Lampung between 2013 – 2021 and met the inclusion and exclusion criteria. The association between breast cancer subtypes and the incidence and metastase sites were tested using the Chi-Square test.

RESULT:This study found a significant association between breast cancer subtypes and the incidence of metastases (p <0.05). The TNBC subtype had a more frequent rate of metastases (34.5%) than the other subtypes (31% luminal B, 20.7% luminal A, and HER2+ 13.8%). The study also revealed a relationship between ER status and the incidence of metastases (p < 0.05). The luminal A subtype tends to metastasize to the liver, luminal B tends to metastasize to the bone, HER2+ tends to metastasize to the lung and liver, and TNBC tends to metastasize to the lung. However, no significant association was found between breast cancer subtypes and metastatic sites.

CONCLUSION:There was a significant association between breast cancer subtypes and the incidence of metastases, but not with the metastatic sites.

 

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References

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Additional Files

Published

2023-11-29

How to Cite

1.
Nurmayeni, Islamy N, Tjiptaningrum A, Siregar BA, Kusumaningtyas A, Windarti I. Breast Cancer Metastases Based on Molecular Subtypes at RSUD Dr. H. Abdul Moeloek Lampung. Medica Hospitalia J. Clin. Med. [Internet]. 2023 Nov. 29 [cited 2024 Oct. 9];10(3):270-6. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/904

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