Correlation Between Testosterone Level With HBA1C Level As Glycemic Control Marker Among Type 2 Diabetes Mellitus Patient
DOI:
https://doi.org/10.36408/mhjcm.v10i3.941Keywords:
Diabetes Mellitus, Glycemic, HbA1C, TestosteroneAbstract
BACKGROUND: Type 2 Diabetes Mellitus could cause various complications due to formation of advanced glycation end products (AGEs). The AGEs could destroy many organs into cellular level, one of them is testis, then causing testosterone production deficiency, and hypogonadism. Meanwhile, the AGEs formation in vivo will depend on on mean glucose level in T2DM patient. HbA1C is one of the most common parameter used to asses glycemic control among T2DM patient.
OBJECTIVE: This research was conducted to find out the correlation between serum total testosterone with HbA1C level among T2DM patient
METHOD:Research subject was collected from Outpatient Polyclinic of Internal Medicine Departement Hasan Sadikin Hospital. HbA1C examination was conducted with turbidimetry method, meanwhile total testosterone level was performed with ELISA method. The examination of research parameter was done at Clinical Laboratory Installation of Hasan Sadikin Bandung
RESULT: During sample collection periode, 70 patients was collected and fulfilled the inclusion criteria, 18 of 70 subjects has low testosteron level with Mean (SD): 424, 48 (204,82) ng/mL. Correlationntesting between the variables showed r = -0,619 , and p-value <0.001, which means strong and significant correlation between total testosterone and HbA1C among T2DM patient.
CONCLUSION: There was strong and significant correlation between total testosterone with HbA1C level among T2DM patients, further research could be conducted with prospective cohort method or using free testosterone examination.
Downloads
References
1. Konsensus pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia. 2019:1-12
2. World Health Organization. Country and regional data on diabetes. 2019 Tersedia dari: http://www.who.int/diabetes/ facts/world_figures/en/index5.html
3. Powers Diabetes Mellitus. Dalam: Jameson JL, editor. Harrison's Endocrinology. Edisi ke-4. New York: McGraw-Hill Companies; 2017. hlm. 421-35
4. Xia Jw, Tan Sj, Zhang Xl, Jun T, Sun Xk, Ling W. Correlation of serum testosterone with insulin resistance in elderly male type 2 diabetes mellitus patients with J Diabetes Invest 2017. 2015:1-4
5. Bhasin S, Jameson Disorders of the Testes and Male Reproductive Systems. Dalam: Jameson JL, editor. Harrison's Endocrinology. Edisi ke-2. New York: McGraw-Hill Companies; 2010. hlm. 156-77
6. Maiorino MI, Bellastella G, Esposito K. Diabetes and sexual dysfunction: current perspectives. Diabetes, Metabolic Syndrome and Obesity: Targets and 2018;7:95-103
7. Pitteloud N, Hardin M, Dwyer AA, Valassi E, Yialamas M, Elahi D, et al. Increasing Insulin Resistance Is Associated with a Decrease in Leydig Cell Testosterone Secretion in Clin Endocrinol Metab. 2015;90:2636–41
8. Turbidimetric inhibition immunoassay (TINIA) for the in vitro determination of hemoglobin A1c. 2013
9. Elecsys® Testosterone II Electrochemiluminescence immunoassay (ECLIA) for the in vitro quantitative determination of testosterone in human serum and plasma. Roche Diagnostics Ltd. 2012:1-2
10. Beatrice AM, Dutta D, Kumar M, Shivaprasad KS, Sinha A, Ray S. Testosterone levels and type 2 diabetes in men: current knowledge and clinical implications. Diabetes Metabolic Syndrome and Obesity: Targets and Therapy. 2017;7:481-6
11. Phillips KP, Tanphaichitr N. Mechanisms of obesity-induced male infertility Expert Review of Endocrinology & Metabolism. 2018;5(2):229-51
12. Mammi C, Calanchini M, Antelmi A, Cinti F, Rosano GMC, Lenzi A, et al. Androgens and Adipose Tissue inMales: A Complex and Reciprocal Interplay. Int J Endocrinol. 2017:1-8
13. Wang Y, Rimm EB, Stampfer MJ, Willett WC, Hu FB. Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr. 2015;81:555-63
14. Anupam, B., Shivaprasad, C., Sridevi, A. et al. Association of total and calculated free testosterone with androgen deficiency symptoms in patients with type 2 diabetes. Int J Impot Res 32, 289–296 (2020). https://doi.org/10.1038/s41443-019-0144-9
15. Saghier EOAE, Shebl SE, Fawzy OA, Eltayeb IM, Bekhet LMA, Gharib A. Androgen Deficiency and Erectile Dysfunction in Patients with Type 2 Diabetes. Clin Med Insight: Endocrinol Diab. 2019;8:55-62
16. Grossmann M, Thomas MC, Panagiotopoulos S, Sharpe K, MacIsaac RJ, Clarke S, et al. Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes. J Clin Endocrinol Metab. 2018;93(5):1834-40
Additional Files
Published
How to Cite
Issue
Section
Citation Check
License
Copyright (c) 2023 Raja Iqbal Mulya Harahap, Nina Tristina, Imas Nurhayati, Sylvia Rachmayati
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Copyrights Notice
Copyrights:
Researchers publishing manuscrips at Medica Hospitalis: Journal of Clinical Medicine agree with regulations as follow:
Copyrights of each article belong to researchers, and it is likewise the patent rights
Researchers admit that Medica Hospitalia: Journal of Clinical Medicine has the right of first publication
Researchers may submit manuscripts separately, manage non exclusive distribution of published manuscripts into other versions (such as: being sent to researchers’ institutional repository, publication in the books, etc), admitting that manuscripts have been firstly published at Medica Hospitalia: Journal of Clinical Medicine
License:
Medica Hospitalia: Journal of Clinical Medicine is disseminated based on provisions of Creative Common Attribution-Share Alike 4.0 Internasional It allows individuals to duplicate and disseminate manuscripts in any formats, to alter, compose and make derivatives of manuscripts for any purpose. You are not allowed to use manuscripts for commercial purposes. You should properly acknowledge, reference links, and state that alterations have been made. You can do so in proper ways, but it does not hint that the licensors support you or your usage.
