Correlation Between Brixia Score Imaging and Clinical Laboratory Results In Severe-Critical Covid-19 Patients Receiving Standard Therapy Compared To Tocilizumab

Authors

  • Aulia Fitriani Department of Radiology,Faculty of Medicine Diponegoro University/Kariadi Hospital Semarang, Indonesia
  • Frederica Mardiana Wahyuni Department of Radiology,Faculty of Medicine Diponegoro University/Kariadi Hospital Semarang, Indonesia
  • Bambang Satoto Department of Radiology,Faculty of Medicine Diponegoro University/Kariadi Hospital Semarang, Indonesia
  • Thomas Handoyo Department of Internal Medicine, Faculty of Medicine, Diponegoro University/ Kariadi Hospital Semarang, Indonesia
  • Antonius Gunawan Santoso Department of Radiology,Faculty of Medicine Diponegoro University/Kariadi Hospital Semarang, Indonesia
  • Christina Hari Nawangsih Department of Radiology,Faculty of Medicine Diponegoro University/Kariadi Hospital Semarang, Indonesia
  • Nurdopo Baskoro Department of Radiology,Faculty of Medicine Diponegoro University/Kariadi Hospital Semarang, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v11i2.991

Keywords:

COVID-19, Brixia score, tocilizumab, convalescent plasma

Abstract

Background. Coronavirus infection disease 19 (COVID-19) is a global health issue. Brixia score and inflammatory markers can assess COVID-19 severity. Severe-critical phase becomes the main concern of clinicians in the management of COVID-19 to reduce mortality. Standard therapy for moderate to severe COVID-19 is convalescent plasma which functions as an antiviral and immunomodulator, while tocilizumab is an IL-6 antagonist which underlies the occurrence of cytokine storms in severe-critical COVID-19.

Aims. To examine the correlation between the Brixia score and clinical laboratory results in patients with severe-critical degree of Covid-19 who received both standard therapy and tocilizumab

Method. A retrospective cohort study of Brixia score, with clinical laboratory results of D-dimer, fibrinogen, ferritin, and CRP (C-reactive protein) COVID-19 patients with severe-critical phase who were administered standard therapy and tocilizumab who were treated at RSUP DR Kariadi Semarang, then a correlation was carried out between the Brixia score and clinical laboratory results using a correlation test Spearman.

Results. The research data consisted of 72 subjects divided into groups that were adiminstered tocilizumab therapy (36 subjects) and standard therapy (36 subjects). There was a significant correlation between the Brixia score and the D-dimer result with p = 0.024 (p <0.05), correlation coefficient = 0.377 in the standard pre-therapy and post therapy. A p-value of less than 0.05 indicates no significant correlation between the Brixia score and clinical laboratory results before or after tocilizumab therapy.

Conclusion. There is a significant correlation between the Brixia score results and the D-dimer results in COVID-19 patients who are adiministered standard therapy, but not significant correlation in tocilizumab

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Additional Files

Published

2024-07-31

How to Cite

1.
Fitriani A, Wahyuni FM, Satoto B, Handoyo T, Santoso AG, Nawangsih CH, Baskoro N. Correlation Between Brixia Score Imaging and Clinical Laboratory Results In Severe-Critical Covid-19 Patients Receiving Standard Therapy Compared To Tocilizumab. Medica Hospitalia J. Clin. Med. [Internet]. 2024 Jul. 31 [cited 2024 Nov. 11];11(2):188-92. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/991

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