Dasamuka Covid-19

Authors

  • Flora Ramona Sigit Prakoeswa Fakultas Kedokteran Universitas Muhammadiyah Surakarta/ Program Doktoral Fakultas Kedokteran Universitas Airlangga, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v7i1A.457

Keywords:

COVID-19, SARS-CoV-2, Gejala, Tanda, Variasi

Abstract

Pandemi COVID-19 telah menjadi salah satu masalah kesehatan utama di Dunia. Penyakit yang disebabkan oleh SARS-CoV-2 ini menular dengan cepat via droplet. Kegagalan mengenali gejala awal COVID-19 berperan dalam terlambatnya melakukan isolasi penderita untuk mencegah penularan dan pemberian penanganan dini untuk menghambat komplikasi. Manifestasi klinis penyakit tidak hanya terbatas pada gangguan pernapasan. Laporan kasus dan studi terbaru dari berbagai tempat telah melaporkan keterlibatan sistem organ lain dalam penyakit COVID-19, seperti gastrointestinal dan integumen. Kemampuan sistem imunitas tubuh yang adekuat di fase awal infeksi menjadi salah satu faktor penentu prognosis bagi penderita COVID-19. Artikel review ini bertujuan untuk mengkaji literatur yang membahas patogenesis, manifestasi klinis, dan karakteristik COVID-19 pada berbagai sistem organ. Pemahaman mengenai karakteristik, patogenesis, dan identifikasi gejala awal dapat membantu meminimalisir transmisi dan komplikasi dari COVID-19.

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References

1. Jin YH, Cai L, Cheng ZS, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Med J Chinese People’s Lib Army. 2020;45(1):1-20. doi:10.11855/j.issn.0577-7402.2020.01.01
2. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
3. Coleman JJ, Manavi K, Marson EJ, Botkai AH, Sapey E. COVID-19: to be or not to be; that is the diagnostic question. Postgrad Med J. 2020;96(1137):392-398. doi:10.1136/postgradmedj-2020-137979
4. Ni W, Yang X, Yang D, et al. Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. Crit Care. 2020;24(1):1-10. doi:10.1186/s13054-020-03120-0
5. Cao C, Chen M, He L, Xie J, Chen X. Clinical features and outcomes of COVID-19 patients with gastrointestinal symptoms. Crit Care. 2020;24(1):1-3. doi:10.1186/s13054-020-03034-x
6. Tsivgoulis G, Palaiodimou L, Katsanos AH, et al. Neurological manifestations and implications of COVID-19 pandemic. Ther Adv Neurol Disord. 2020;13:1-14. doi:10.1177/1756286420932036
7. Wrapp D, Wang N, Corbett KS, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science (80- ). 2020;367(6483):1260-1263. doi:10.1126/science.aax0902
8. Li C, Zhao C, Bao J, Tang B, Wang Y, Gu B. Laboratory diagnosis of coronavirus disease-2019 (COVID-19). Clin Chim Acta. 2020;510(June):35-46. doi:10.1016/j.cca.2020.06.045
9. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-513. doi:10.1016/S0140-6736(20)30211-7
10. Ji W, Wang W, Zhao X, Zai J, Li X. Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human. J Med Virol. 2020;92(4):433-440. doi:10.1002/jmv.25682
11. Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020;19(4):1351-1360. doi:10.1021/acs.jproteome.0c00129
12. Zhou P, Yang X Lou, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273. doi:10.1038/s41586-020-2012-7
13. Xu X, Chen P, Wang J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci. 2020;63(3):457-460. doi:10.1007/s11427-020-1637-5
14. Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382(13):1199-1207. doi:10.1056/NEJMoa2001316
15. Yu W Bin, Tang G Da, Zhang L, Corlett RT. Decoding the evolution and transmissions of the novel pneumonia coronavirus (SARS-CoV-2 / HCoV-19) using whole genomic data. Zool Res. 2020;41(3):247-257. doi:10.24272/j.issn.2095-8137.2020.022
16. Chan JFW, Yuan S, Kok KH, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514-523. doi:10.1016/S0140-6736(20)30154-9
17. Wang J, Zhao S, Liu M, et al. ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism. medRxiv. 2020:2020.02.05.20020545. doi:10.1101/2020.02.05.20020545
18. Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for Gastrointestinal Infection of SARS-CoV-2 Fei. Gastroenterology. 2020;158(6):1831-1833.e3.
19. Xia J, Tong J, Liu M, Shen Y, Guo D. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. J Med Virol. 2020;92(6):589-594. doi:10.1002/jmv.25725
20. Wang L, Wang Y, Ye D, Liu Q. Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence. Int J Antimicrob Agents. 2020;55(6):105948. doi:10.1016/j.ijantimicag.2020.105948
21. Bai Y, Yao L, Wei T, et al. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA - J Am Med Assoc. 2020;323(14):1406-1407. doi:10.1001/jama.2020.2565
22. Wang D, Hu B, Hu C, et al. The reproductive number of COVID- 19 is higher compared to SARS coronavirus. J ofTravel Med. 2020;27(2):1-4. doi:10.1001/jama.2020.1585
23. Matthay MA, Zemans RL, Zimmerman GA, et al. Acute respiratory distress syndrome. Nat Rev Dis Prim. 2019;5(1):18. doi:10.1038/s41572-019-0069-0
24. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA - J Am Med Assoc. 2020;323(11):1061-1069. doi:10.1001/jama.2020.1585
25. Lee Y, Min P, Lee S, Kim SW. Prevalence and duration of acute loss of smell or taste in COVID-19 patients. J Korean Med Sci. 2020;35(18):1-6. doi:10.3346/JKMS.2020.35.E174
26. Li Q, Guan X, Wu P, et al. Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med. 2020;382(14):1370-1371. doi:10.1056/nejmoa2001316
27. Shen KL, Yang YH. Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue. World J Pediatr. 2020;16(3):219-221. doi:10.1007/s12519-020-00344-6
28. Smits SL, De Lang A, Van Den Brand JMA, et al. Exacerbated innate host response to SARS-CoV in aged non-human primates. PLoS Pathog. 2010;6(2). doi:10.1371/journal.ppat.1000756
29. Gupta A, Madhavan M V., Sehgal K, et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26(7):1017-1032. doi:10.1038/s41591-020-0968-3
30. Behzad S, Aghaghazvini L, Radmard AR, Gholamrezanezhad A. Extrapulmonary manifestations of COVID-19: Radiologic and clinical overview. Clin Imaging. 2020;66(July):35-41. doi:10.1016/j.clinimag.2020.05.013
31. Matar S, Oulès B, Sohier P, et al. Cutaneous manifestations in SARS-CoV-2 infection (COVID-19): a French experience and a systematic review of the literature. J Eur Acad Dermatology Venereol. 2020:2-5. doi:10.1111/jdv.16775
32. Guan W, Ni Z, Hu YHYYH, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032
33. Mao L, Jin H, Wang M, et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683-690. doi:10.1001/jamaneurol.2020.1127
34. Cheng Y, Luo R, Wang K, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;97(5):829-838. doi:10.1016/j.kint.2020.03.005
35. Zhang G, Hu C, Luo L, et al. Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China. J Clin Virol. 2020;127(April):104364. doi:10.1016/j.jcv.2020.104364
36. Zhang J jin, Dong X, Cao Y yuan, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy Eur J Allergy Clin Immunol. 2020;75(7):1730-1741. doi:10.1111/all.14238
37. Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020;18(6):1421-1424. doi:10.1111/jth.14830
38. Li J, Wang X, Chen J, Zuo X, Zhang H, Deng A. COVID-19 infection may cause ketosis and ketoacidosis. Diabetes, Obes Metab. 2020;(April):1-7. doi:10.1111/dom.14057
39. Galván Casas C, Català A, Carretero Hernández G, et al. Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases. Br J Dermatol. 2020;183(1):71-77. doi:10.1111/bjd.19163
40. Joob B, Wiwanitkit V. COVID-19 can present with a rash and be mistaken for dengue. J Am Acad Dermatol. 2020;82(5):e177. doi:10.1016/j.jaad.2020.03.036
41. Hunt M, Koziatek C. A Case of COVID-19 Pneumonia in a Young Male with Full Body Rash as a Presenting Symptom. Clin Pract Cases Emerg Med. 2020;4(2):2019-2021. doi:10.5811/cpcem.2020.3.47349
42. Shanshal M. Is the Coronavirus (COVID-19) Pandemic an Indication to Temporarily Modify Dermatological Management Plans? J Drugs Dermatology. 2020;19(4):JO00420.
43. Lebwohl M, Rivera-Oyola R, Murrell DF. Should biologics for psoriasis be interrupted in the era of COVID-19? J Am Acad Dermatol. 2020;82(5):1217-1218. doi:10.1016/j.jaad.2020.03.031
44. Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032
45. Pan L, Mu M, Yang P, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: A descriptive, cross-sectional, multicenter study. Am J Gastroenterol. 2020;115(5):766-773. doi:10.14309/ajg.0000000000000620
46. Musa S. Hepatic and gastrointestinal involvement in coronavirus disease 2019 (COVID-19): What do we know till now? Arab J Gastroenterol. 2020;21(1):3-8. doi:10.1016/j.ajg.2020.03.002
47. Wei X-S, Wang X, Niu Y-R, et al. Clinical Characteristics of SARS-CoV-2 Infected Pneumonia with Diarrhea. SSRN Electron J. 2020. doi:10.2139/ssrn.3546120
48. Fan Z, Chen L, Li J, et al. Clinical Features of COVID-19-Related Liver Functional Abnormality. Clin Gastroenterol Hepatol. 2020;18(7):1561-1566. doi:10.1016/j.cgh.2020.04.002
49. Li L, Li S, Xu M, et al. Risk factors related to hepatic injury in patients with corona virus disease 2019. 2020. doi:10.1101/2020.02.28.20028514
50. Feng J, Jia Y, Ph D, et al. Clinical characteristics of 82 death cases with COVID-19. 2020.
51. Jothimani D, Venugopal R, Abedin MF, Kaliamoorthy I, Rela M. COVID-19 and Liver. J Hepatol. June 2020. doi:10.1016/j.jhep.2020.06.006
52. Zhang H, Kang Z, Gong H, et al. The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes. 2020. doi:10.1101/2020.01.30.927806
53. Liang W, Feng Z, Rao S, et al. Diarrhoea may be underestimated: A missing link in 2019 novel coronavirus. Gut. 2020;69(6):1141-1143. doi:10.1136/gutjnl-2020-320832
54. Cha MH, Regueiro M, Sandhu DS. Gastrointestinal and hepatic manifestations of COVID-19: A comprehensive review. World J Gastroenterol. 2020;26(19):2323-2332. doi:10.3748/wjg.v26.i19.2323
55. Tian D, Ye Q. Hepatic complications of COVID-19 and its treatment. J Med Virol. 2020. doi:10.1002/jmv.26036
56. Argenzian MG, Bruc SL, Slate CL, et al. Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: Retrospective case series. BMJ. 2020;369(March). doi:10.1136/bmj.m1996
57. Izquierdo-Dominguez A, Rojas-Lechuga M, Mullol J, Alobid I. Olfactory dysfunction in the COVID-19 outbreak. J Investig Allergol Clin Immunol. 2020;30(5). doi:10.18176/jiaci.0567
58. Costa KVT d., Carnaúba ATL, Rocha KW, Andrade KCL de, Ferreira SMS, Menezes P de L. Olfactory and taste disorders in COVID-19: a systematic review. Braz J Otorhinolaryngol. 2020;(January). doi:10.1016/j.bjorl.2020.05.008
59. Morassi M, Bagatto D, Cobelli M, et al. Stroke in patients with SARS-CoV-2 infection: case series. J Neurol. 2020;267(8):2185-2192. doi:10.1007/s00415-020-09885-2
60. Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T. The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngol - Head Neck Surg (United States). 2020;163(1):3-11. doi:10.1177/0194599820926473
61. Lechien JR, Chiesa-Estomba CM, De Siati DR, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Oto-Rhino-Laryngology. 2020;277(8):2251-2261. doi:10.1007/s00405-020-05965-1
62. Giacomelli A, Pezzati L, Conti F, et al. Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study. Clin Infect Dis. 2020;71(15):889-890. doi:10.1093/cid/ciaa330
63. Yaghi S, Ishida K, Torres J, et al. SARS-CoV-2 and Stroke in a New York Healthcare System. Stroke. 2020;(July):2002-2011. doi:10.1161/STROKEAHA.120.030335
64. Li Y, Li M, Wang M, et al. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Stroke Vasc Neurol. July 2020:svn-2020-000431. doi:10.1136/svn-2020-000431
65. Avula A, Nalleballe K, Narula N, et al. COVID-19 presenting as stroke. Brain Behav Immun. 2020;87:115-119. doi:10.1016/j.bbi.2020.04.077
66. Ellul MA, Benjamin L, Singh B, et al. Neurological associations of COVID-19. Lancet Neurol. 2020;4422(20):2-3. doi:10.1016/S1474-4422(20)30221-0
67. Whittaker A, Anson M, Harky A. Neurological Manifestations of COVID?19: A systematic review and current update. Acta Neurol Scand. 2020;142(1):14-22. doi:10.1111/ane.13266
68. Connors JM, Levy JH. Thromboinflammation and the hypercoagulability of COVID?19. J Thromb Haemost. 2020;18:1559-1561. doi:10.1111/jth/14849
69. Wu Y, Xu X, Chen Z, et al. COVID-19 and Nervous System. Brain Behav Immun. 2020;(January). doi:10.1016/j.bbi.2020.03.031
70. Yu Y, Xu D, Fu S, et al. Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study. Crit Care. 2020;24(1):219. doi:10.1186/s13054-020-02939-x
71. Ahmed I, Azhar A, Eltaweel N, Tan BK. First COVID?19 maternal mortality in the UK associated with thrombotic complications. Br J Haematol. 2020;190(1). doi:10.1111/bjh.16849
72. Lippi G, South AM, Henry BM. Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19). Ann Clin Biochem. 2020;57(3):262-265. doi:10.1177/0004563220922255
73. Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475-481. doi:10.1016/S2213-2600(20)30079-5
74. Hirsch JS, Ng JH, Ross DW, et al. Acute kidney injury in patients hospitalized with COVID-19. Kidney Int. 2020;98:209-218. doi:10.1017/CBO9781107415324.004
75. Cui X, Yu X, Wu X, et al. Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study. Kidney Blood Press Res. 2020;100029(2):1-11. doi:10.1159/000509517
76. Xiong F, Tang H, Liu L, et al. Clinical Characteristics of and Medical Interventions for COVID-19 in Hemodialysis Patients in Wuhan, China. J Am Soc Nephrol. 2020;31(7):1387-1397. doi:10.1681/ASN.2020030354
77. Alberici F, Delbarba E, Manenti C, et al. A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia. Kidney Int. 2020;97:1083-1086. doi:10.1017/CBO9781107415324.004
78. Martinez-Rojas MA, Vega-Vega O, Bobadilla NA. Is the kidney a target of SARS-CoV-2? Am J Physiol Renal Physiol. 2020;318(6):F1454-F1462. doi:10.1152/ajprenal.00160.2020
79. Diao B, Wang C, Wang R, et al. Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. 2020;2. doi:10.1101/2020.03.04.20031120
80. Kunutsor SK, Laukkanen JA. Renal complications in COVID-19: a systematic review and meta-analysis. Ann Med. 2020;0(0):1-9. doi:10.1080/07853890.2020.1790643
81. Guan W, Liang W, Zhao Y, et al. Comorbidity and Its Impact on 1590 Patients with Covid-19 in China: A Nationwide Analysis. The European Respiratory Journal [Revista En Internet] 2020 [Acceso 11 de Mayo de 2020]; 1-56.; 2020. doi:10.1183/13993003.00547-2020 LK - http://ucelinks.cdlib.org:8888/sfx_local?sid=EMBASE&sid=EMBASE&issn=13993003&id=doi:10.1183%2F13993003.00547-2020&atitle=Comorbidity+and+its+impact+on+1590+patients+with+Covid-19+in+China%3A+A+Nationwide+Analysis&stitle=Eur.+Respir.+J.&title=The+European+respiratory+journal&volume=&issue=&spage=&epage=&aulast=Guan&aufirst=Wei-Jie&auinit=W.-J.&aufull=Guan+W.-J.&coden=&isbn=&pages=-&date=2020&auinit1=W&auinitm=-J
82. Shi S, Qin M, Shen B, et al. Association of Cardiac Injury with Mortality in Hospitalized Patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020:1-8. doi:10.1001/jamacardio.2020.0950
83. Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17(5):259-260. doi:10.1038/s41569-020-0360-5
84. Kim I-C, Kim HA, Park JS, Nam C-W. Updates of Cardiovascular Manifestations in COVID-19: Korean Experience to Broaden Worldwide Perspectives. Korean Circ J. 2020;50(7):543. doi:10.4070/kcj.2020.0205
85. Gavriatopoulou M, Korompoki E, Fotiou D, et al. Organ-specific manifestations of COVID-19 infection. Clin Exp Med. 2020;(0123456789). doi:10.1007/s10238-020-00648-x
86. Terpos E, Ntanasis-Stathopoulos I, Elalamy I, et al. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834-847. doi:10.1002/ajh.25829
87. Sonja A. Rasmussen, MD, MS JCS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-. Ann Oncol. 2020;(January):19-21. doi:10.1007/s00134-020-05991-x.Bizzarro
88. Zhang X, Tan Y, Ling Y, et al. Viral and host factors related to the clinical outcome of COVID-19. Nature. 2020;(March). doi:10.1038/s41586-020-2355-0
89. Helms J, Tacquard C, Severac F, et al. High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med. 2020;46(6):1089-1098. doi:10.1007/s00134-020-06062-x
90. Llitjos JF, Leclerc M, Chochois C, et al. High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. J Thromb Haemost. 2020;18(7):1743-1746. doi:10.1111/jth.14869
91. Z W, JM M. Characteristics of and important lessons from the coronavirus disease 2019(COVID-19) outbreak in China. Jama. 2020;2019:10.1001/jama.2020.2648. doi:10.1001/jama.2020.2648
92. Liu F, Long X, Zhang B, Zhang W, Chen X, Zhang Z. ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection. Clin Gastroenterol Hepatol. 2020;18(9):2128-2130.e2. doi:10.1016/j.cgh.2020.04.040

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2020-08-28

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1.
Sigit Prakoeswa FR. Dasamuka Covid-19. Medica Hospitalia J. Clin. Med. [Internet]. 2020 Aug. 28 [cited 2024 Mar. 28];7(1A):231-40. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/457

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