COVID-19 :Correlation Between CRP and LDH to Disease Severity and Mortality In Hospitalized COVID-19 Patients

Authors

  • Rizal Muldani Tjahyadi Lab/SMF Pulmnologi dan Kedokteran Respirasi Fakultas Kedokteran, Universitas Brawijaya, Malang, Indonesia, Indonesia
  • Triwahju Astuti Lab/SMF Pulmnologi dan Kedokteran Respirasi Fakultas Kedokteran, Universitas Brawijaya, Malang, Indonesia, Indonesia
  • Aditya Sri Listyoko Lab/SMF Pulmnologi dan Kedokteran Respirasi Fakultas Kedokteran, Universitas Brawijaya, Malang, Indonesia, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v7i1A.467

Keywords:

COVID-19, LDH, CRP, P/F Ratio

Abstract

Background and Objective:COVID–19 is a newly emerging disease and considered an emergency health problem, worldwide.It has a wide range of clinical features, from mild fever to severe respiratory failure that leads to a higher mortality rate. Previous studies state that CRPhas a very strong positive correlation with the diameter of the lung lesion, and in intensive care patients had a higher level of LDH. This study aims to determine the correlation between CRP, LDH and disease severity and mortality in hospitalized COVID-19 patients. Methods: We conducted a retrospective cohort, a single-center study including  69 laboratory-confirmed patients in our hospital in Malang City, Indonesia from April - June 2020. Result: Subjects consisted of 26 patients (37.7%) in the mild-moderate group and 43 patients in severe group (62.3%).Statistical analysis showed CRP and LDH associated with disease severity (p=0.011 and p<0.001). Analysis of CRPand LDH in survivor and non-survivior group showed that CRP and LDH also asscociated with mortality in hospitalized COVID-19 patients (p=0.034 and 0.002). We also evaluate CRP and LDH with degrees of hypoxemia  by assessed P/F ratio. Statistical analysis showed that CRP did not correlate with degrees of hypoxemia (p=0.079) but LDH inverse correlate with degrees of hypoxemia (p<0.001, pearson correlation = -0,489)  Conclusion: In our retrospective cohort study demonstrated LDH and CRP can be a crucial indicator to predict severity and mortality for hospitalized COVID-19 patients and LDH may usefull test for predict early identification of patients who become respiratory failure or ARDS.

Keywords: COVID-19, LDH, CRP, P/F Ratio

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Additional Files

Published

2020-08-28

How to Cite

1.
Tjahyadi RM, Astuti T, Listyoko AS. COVID-19 :Correlation Between CRP and LDH to Disease Severity and Mortality In Hospitalized COVID-19 Patients. Medica Hospitalia J. Clin. Med. [Internet]. 2020 Aug. 28 [cited 2024 Nov. 22];7(1A):144-9. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/467

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