DIFFERENCES IN HISTORY of PREVIOUS THYROID DISEASE, METASTASIS AND ULTRASOUND INSPECTION ABNORMALITIES BETWEEN CLASSICAL PAPILLARY THYROID CARCINOMA PATIENTS AND FOLLICULAR VARIANTS IN Dr. KARIADI HOSPITAL SEMARANG

  • Nabila Zenska Firdauzi Putri Fakultas Kedokteran Universitas Diponegoro
  • Hermawan Istiadi Department of Anatomy Pathology, Faculty of Medicine, Diponegoro University
  • Edmond Rukmana Wikanta Department of Surgery, Sub-Division of Oncology Surgery, Faculty of Medicine, Diponegoro University
  • Ika Pawitra Miranti Department of Anatomy Pathology, Faculty of Medicine, Diponegoro University
Keywords: Classic papillary carcinoma of the thyroid, follicular variant papillary thyroid carcinoma, Previous history of thyroid disease, metastasis, ultrasound examination abnormalities

Abstract

Background: Papillary thyroid carcinoma (PTC) is the most common carcinoma, accounting for more than 90% of all malignancies, where the most variants are classic papillary thyroid carcinoma and follicular variant papillary thyroid carcinoma (PTCVF). The characteristics of previous thyroid disease history, regional metastases, and ultrasound examination results can influence the clinical examination between the two variants of PTC, namely classic PTC and PTCVF. Aim: Understanding the differences in the history of previous thyroid disease, metastases, and ultrasound examination abnormalities between Classical Papillary Carcinoma and Follicular variants at Dr. Kariadi Hospital, Semarang. Methods: A cross sectional study with consecutive sampling method in classic PTC and PTCVF patients in Dr. Kariadi Hospital, Semarang who was diagnosed in the period January to June 2019. In this study, the number of samples obtained was 18 medical records with classic PTC cases and 20 medical records with PTCVF cases. The dependent variables, namely history of previous thyroid disease, regional metastases, and ultrasound examination abnormalities, all of which were on an ordinal scale, were analyzed using non-parametric chi-square test and Fisher's Exact test. Results: In the non-parametric chi-square test and Fisher's Exact test, the results were not significant (p = 0.474), regional metastases were not significant (p = 0.359), ultrasound size abnormalities were not significant (p = 0.323), and abnormalities. ultrasound nodal was not significant (p = 0.595). Conclusion: There was no statistically significant difference in the history of previous thyroid disease, regional metastases, and ultrasound examination abnormalities between classic PTC and PTCVF patients at Dr. Kariadi Hospital, Semarang.

Downloads

Download data is not yet available.

References

Huang H, Rusiecki J, Zhao N, Chen Y, Ma S, Yu H, et al. Thyroid-Stimulating Hormone, Thyroid Hormones and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study [Internet]. 2019 [cited 2020 Feb 5];26(8):1–20. Available from : https://www.ncbi.nlm.nih.gov/pmc/

Parura Y, Pontoh V, Merung M. Pola Kanker Tiroid Periode Juli 2013-juni 2016 di RSUP Prof. Dr. R. D Kandou Manado. Jurnal e-Clinic [Internet]. 2016 [cited 2020 Feb 5];4(2):1-5. Available from : https://ejournal.unsrat.ac.id/

Putri E, Khambri D, Rusjdi SR. Hubungan Daerah Tempat Tinggal dengan Gambaran Histopatologi Karsinoma Tiroid pada Masyarakat Sumatera Barat. Jurnal Kesehatan Andalas [Internet]. 2017 [cited 2020 Feb 5];36(21):171–4. Available from : http://jurnal.fk.unand.ac.id

Ridho MA, Qodir N, Triwani. Karakteristik Pasien Karsinoma Tiroid Papiler di Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Periode Januari-Desember 2016. Majalah Kedokteran Sriwijaya, Th 50. [Internet]. 2018 [cited 2020 Feb 5];50(4):1-9. Available from : https://ejournal.unsri.ac.id

Fitriyani H. Hubungan Kadar Serum Tsh, T3 dan T4 dengan Tipe Histopatologi Karsinoma Tiroid di Departemen Patologi Anatomik Fakultas Kedokteran USU/RSUP H. Adam Malik Medan Tahun 2013-2015 [Internet]. 2016 [cited 2020 Feb 5]. Available from: http://repositori.usu.ac.id/

Lewi?ski A, Adamczewski Z, Zygmunt A, Markuszewski L, Karbownik-Lewi?ska M, Stasiak M. Correlations between Molecular Landscape and Sonographic Image of Different Variants of Papillary Thyroid Carcinoma. Jurnal Clinical Medicine [Internet]. 2019 [cited 2020 Feb 5];Nov 8;8(11):1916. Available from : http://www.mdpi.com/

Ming J, Liu Z, Zeng W, Maimaiti Y, Guo Y, Nie X, et al. Association between BRAF and RAS mutations, and RET rearrangements and the clinical features of papillary thyroid cancer. Int J Clin Exp Pathol [Internet]. 2015 [cited 2020 Feb 5];8(11):15155–15162. Available from : https://www.ncbi.nlm.nih.gov/pmc/

Katoh H, Yamashita K, Enomoto T. Classification and General Considerations of Thyroid Cancer. Annals Clinical Pathology [Internet]. 2015 [cited 2020 Feb 8]; 3(1):1–9. Available from : https://www.jscimedcentral.com

Septina L, Zaid M, Zuraidah E, Stephanie A. Peran Rearrangement RET/PTC pada Karsinoma Papiler Tiroid. Fakultas Kedokteran Universitas Indonesia [Internet]. 2019 [cited 2020 feb 5];6(1):70-81. Available from : http://majalahpratistapatologi.com/

Ridho MA. Karakteristik Pasien Karsinoma Tiroid Papiler di Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Periode Januari–Desember 2016. Jurnal e-Clinic [Internet]. 2018 [cited 2020 Feb 6]; 50 (4):1-9. Available from : https://ejournal.unsri.ac.id

Armerinayanti NW. Goiter Sebagai Faktor Predisposisi Karsinoma Tiroid. Warmadewa Medical Journal [Internet]. 2017 [cited 2020 Feb 6];1(2):42–50. Available from : http://ejournal.warmadewa.ac.id/

Lloyd R., Osamura RY, Kloppel G, J R. WHO Classification of Tumours of Endocrine Organs. USA: World Health Organization; 2017.

Armerinayanti NW, Mulyadi IK, Putu L, Indrayani I. Ekspresi Matriks Metaloproteinase 9 pada Infiltrasi Karsinoma Tiroid Papiler Klasik dan Varian Folikuler. Departemen Patologi Anatomi Fakultas Kedokteran, Universitas Udayana Denpasar [Internet]. 2017 [cited 2020 Feb 6];26(2):1-7. Available from : http://www.pps.unud.ac.id

Antika ID, Hanriko R, Larasati TA. Studi Diagnostik Ultrasonografi dalam Mendiagnosis Nodul Tiroid di RSUD Dr. H. Abdul Moeloek Bandar Lampung. Kedokteran Unila [Internet]. 2017 [cited 2020 Feb 7];8(2). Available from : http://juke.kedokteran.unila.ac.id/

Adham M, Aldino N. Diagnosis dan Tatalaksana Karsinoma Tiroid Berdiferensiasi. Oto Rhino Laryngologica Indonesiana [Internet]. 2018 [cited 2020 Feb 7];48(2):197-209. Available from : https://www.orli.or.id

Armerinayanti NM. Perbedaan Skor Ekspresi Matriks Metaloproteinase 9 pada Karsinoma Tiroid Papiler Varian Klasik dan Varian Folikuler dengan Infiltrasi Intrakompartemen dan Ekstrakompartemen. Program Studi Ilmu Biomedik Universitas Udayana [Internet]. 2015 [cited 2020 Feb 7];26(2):1-7. Available from: http://erepo.unud.ac.id/

Chen H, Izevbaye I, Chen F, Weinstein B. Recent Advances in Follicular Variant of Papillary Thyroid Carcinoma. The North American Journal of Medicine and Science [Internet]. 2012 [cited 2020 Feb 8];5(4):212–216. Available from : https://www.najms.com/

Erickson LA. Atlas of Endocrine Pathology. American Journal of Clinical Pathology. Rochester,USA: Mayo Clinic College of Medicine; 1998.

Livolsi VA. Papillary thyroid carcinoma?: an update. Modern Pathology [Internet]. 2011 [cited 2020 Feb 8];Apr;24 Suppl 2:1–9. Available from : https://pubmed.ncbi.nlm.nih.gov/

Crosby H, Pontoh V, Merung MA, Skripsi K, Kedokteran F, Sam U, et al. Pola kelainan tiroid di RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2013-Desember 2015. Jurnal e-CliniC [Internet]. 2016 [cited Feb 9]; 4(1):1-8. Available from https://ejournal.unsrat.ac.id

Sezer A, Celik M, Bulbul BY, Can N, Tastekin E, Ayturk S, et al. Relationship between lymphovascular invasion and clinicopathological features of papillary thyroid carcinoma. Journal of the Association of Basic Medical Sciences [Internet]. 2017 [cited 2020 Feb 9];17(2):144–151. Available from : https://www.ncbi.nlm.nih.gov/pmc/

Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer [Internet]. 2016 [cited 2020 Feb 10]; 26(1):1–133. Available from : http://seer.cancer.gov/statfacts/html/thyro.html

Abdullah MI, Junit SM, Ng KL, Jayapalan JJ. Papillary Thyroid Cancer?: Genetic Alterations and Molecular Biomarker Investigations. International Journal of Medical Sciences [Internet]. 2019 [cited 2020 Feb 10];16(3):450-460. Available from : https://www.ncbi.nlm.nih.gov/pmc/

Liu C, Chen T, Liu Z. Associations between BRAF and prognostic factors and poor outcomes in papillary thyroid carcinoma: A meta-analysis. World Journal of Surgical Oncology [Internet]. 2016 [cited 2020 Feb 10];14(1):1–12. Available from: https://www.ncbi.nlm.nih.gov/pmc/

Wibowo AS, Herdini C, Udji B, Rianto D. TSH Levels Difference Between Differentiated Thyroid Carcinoma and Benign Thyroid Enlargement. Universitas Gadjah Mada [Internet]. 2018 [cited 2020 Feb 10]. Available from: http://etd.repository.ugm.ac.id/

Kakudo K, Yanhua B, Zhiyan L, Takashi O. Encapsulated papillary thyroid carcinoma , follicular variant?: a misnomer. National Library of Medicine [Internet]. 2012 [cited 2020 Feb 11];Mar;62(3):155–60. Available from : https://pubmed.ncbi.nlm.nih.gov/

Gozali YK. Uji Diagnostik Ultrasonografi dibandingkan dengan biopsi Patologi Anatomi dalam Mendiagnosis Karsinoma Tiroid. J Chem Inf Model [Internet]. 2015 [cited 2020 Feb 11];53(9):1689–1699. Available from : http://eprints.undip.ac.id/

Haser GC, Tuttle RM, Su HK, Alon EE, Bernet V, Brett E, et al. Activated Surveillance for Papillary Thyroid Microcarcinoma?: New Challenges and Opportunities for The Health Care System. National Library of Medicine [Internet]. 2017 [cited 2020 Feb 11];22(5):602–11. Available from : https://pubmed.ncbi.nlm.nih.gov/

Sun X, Shan Z, Teng W. Effects of Increased Iodine Intake on Thyroid Disorders. Endocrinology and Metabolism [Internet]. 2014 [cited 2020 Feb 12];29(3):240–7. Available from : https://www.researchgate.net/

Henke LE, Pfeifer JD, Baranski TJ, Dewees T, Grigsby PW. Long-term outcomes of follicular variant vs classic papillary thyroid carcinoma. Endocrine Connections [Internet].2018 [cited 2020 Feb 12];7(12):1226–1235. Available from : https://www.ncbi.nlm.nih.gov/pmc/

Albi E, Cataldi S, Lazzarini A, Codini M, Beccari T, Ambesi-impiombato FS, et al. Radiation and Thyroid Cancer. International Journal of Molecular Sciences [Internet]. 2017 [cited 2020 Aug 27];18(5):1–11. Available from : https://www.ncbi.nlm.nih.gov/pmc/

Li C, Lee KC, Schneider EB, Zeiger MA. BRAF V600E mutation and Its Association with Clinicopathological Features of Papillary Thyroid Cancer?: A Meta-Analysis. Endocrine Society [Internet]. 2015 [cited 2020 Aug 27];97(12):4559–4570. Available from : https://www.ncbi.nlm.nih.gov/pmc/

Jeon EJ, Jeong YJ. Ultrasonographic Characteristics of the Follicular Variant Papillary Thyroid Cancer according to the Tumor Size. Journal of Korean Medical Science [Internet]. 2016 [cited 2020 Aug 27];31(3):397–402. Available from : https://www.ncbi.nlm.nih.gov/pmc/

Aksoy A, Ally A, Arachchi H, Asa SL, Auman JT, Balasundaram M, et al. Integrated Genomic Characterization of Papillary Thyroid. HHS Public Access [Internet]. 2015 [cited 2020 Aug 27];159(3):676–690. Available from : https://www.ncbi.nlm.nih.gov/pmc/

Published
2021-03-23
Section
Original Article