A Malignant Melanoma of the Penile : A Very Rare Case Report and Literature Review

  • Yanuar Hendra Wijaya Department of General Surgery, Dr Kariadi General Hospital, Medical Faculty Diponegoro University
  • Nanda Daniswara Division of Urology, Department of Surgery, Dr Kariadi General Hospital, Medical Faculty Diponegoro University
  • Ardy Santosa Division of Urology, Department of Surgery, Dr Kariadi General Hospital, Medical Faculty Diponegoro University
  • Mohamad Adi Soedarso Division of Urology, Department of Surgery, Dr Kariadi General Hospital, Medical Faculty Diponegoro University
  • Eriawan Agung Nugroho Division of Urology, Department of Surgery, Dr Kariadi General Hospital, Medical Faculty Diponegoro University
  • Sofyan Rais Addin Division of Urology, Department of Surgery, Dr Kariadi General Hospital, Medical Faculty Diponegoro University
Keywords: partial penectomy, malignant melanoma, inguinal lymph node

Abstract

Background: Malignant melanoma of the penis is very rare, accounting for approximately 1.4% of all primary penile carcinomas. With a small prevalence of penile melanoma, there is lack of data about quality of the therapy. The primary treatment of melanoma of the penile is surgical, although there is a lack of consensus regarding the extent of treatment that is indicated.

Case Report: A 60-year-old Caucasian man came to Division of Urology, Department of Surgery, Dr. Kariadi General Hospital Semarang with chief complaint painless and fast growing lesions on his penile. His general condition was fine, and has a normal vital signs. On the physical examination of penile region, there were found lesions on the ventral of the glans and penile foreskin and covered with blood and pus, with bilateral inguinal lymph nodes and lung metastasis from Multi Slice Computed Tomography. We already performed partial penectomy and bilateral inguinal lymph nodes dissection with histopathological results a malignant melanoma Clark IV. The final stage of penile melanoma was pT2N1M1. We follow-up the patient until 1 year after procedure, and there wasn’t any recurrence.

Conclusion: Malignant melanoma of the penis is rare. Penile melanoma is highly treatable with surgical excision in its early stages because of resistant to both chemotherapy and radiotherapy. Delay in diagnosed and surgical treatment can lead to an adverse prognosis. The anamnesis, physical examination, and imaging studies must be done appropriately to improve the survival.

Downloads

Download data is not yet available.

References

1. Brady KL, Mercurio MG, Brown MD. Malignant Tumors of the Penis. Dermatol Surg. 2013; 39: p527–547.
2. Petersen RO, Sesterhenn IA, David CJ. Urologic Pathology; 3rd edition. Philadelphia : Lippincott Williams & Wilkins, Wolters Kluwer Health; 2009. p573-90.
3. Maruyama Y, Sadahira T, Mitsui Y, Wada K, Tanimoto R, Kobayashi Y, et al. Red nodular melanoma of the penile foreskin: A case report and literature review. Mol Clin Oncol. 2018; 9: p449-52.
4. Koh KH, Geller AC. The public health future of melanoma control. J Am Acad Dermatol. 2011; 65: S3-5.
5. Douglawi A, Masterson TA. Updates on the epidemiology and risk factors for penile cancer. Transl Androl Urol. 2017; 6(5): p785-90.
6. Parker DC. Malignant Dermatologic Disease of the Male Genitalia [Internet]. Medscape. 2018 [cited January 11st 2019]. Available from : https://emedicine.medscape.com/article/454810-overview#a7
7. Pettaway CA, Crook JM, Pagliaro LC. Tumors of the Penis. In : Wein AJ, Kavoussi LR, Partin AW, Peters CA. Campbell-Walsh Urology; 11th edition. Philadelpia : Elsevier, Inc; 37: p846-78.
8. Hakenberg OW, Compérat E, Minhas S, Necchi A, Protzel C, Watkin N. Guidelines on Penile Cancer. European Association of Urology. 2014 [cited January 11st 2019]. Available from : https://uroweb.org/wp-content/uploads/EAU-Guidelines-Penile-Cancer-2015-v2.pdf
9. Bechara GR, Schwindt ABDS, Ornellas AA, da Silva DEA, Lott FM, de Campos FS. Penile primary melanoma: analysis of 6 patients treated at Brazilian national cancer institute in the last eight years. Int Braz J Urol. 2013; 39: p823-31.
10. Jabiles AG, Del Mar EY, Perez GAD, Vera FQ, Montoya LM, Deza CMM. Penile melanoma: a 20-Year analysis of six patients at the National Cancer Institute of Peru, Lima. Ecancermedicalscience. 2017; 11: p731.
11. Strojan P. Role of radiotherapy in melanoma management. Radiol Oncol. 2010; 44(1): p1-12.
12. Yang AS, Champman PB. The History and Future of Chemotherapy for Melanoma. Hematol Oncol Clin North Am. 2009; 23(3): p583–x.
13. Wilson MA, Schuchter LM. Chemotherapy for Melanoma. Cancer Treat Res. 2016;167: p209-29.
14. Velu PP, Cao C, Yan TD. Current surgical management of melanoma metastases to the lung. J Thorac Dis. 2013;5(S3):S274-S276.
15. Van Geel AN, den Bakker MA, Kirkels W, Horenblas S, Kroon BBR, de Wilt JHW, et al. Prognosis of Primary Mucosal Penile Melanoma : A Series of 19 Dutch Patients and 47 Patients from the Literature. Urology. 2007;70(1): p143-7.
Published
2021-03-23