ANTIBIOTIC PRESCRIBING PATTERNS DURING THE COVID-19 PANDEMIC (A CASE STUDY AT DIPONEGORO NATIONAL HOSPITAL)

Authors

  • Dominikus Evano Putra Departemen Kedokteran, Fakultas Kedokteran, Universitas Diponegoro, Indonesia
  • Setyo Gundi Pramudo Bagian Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Diponegoro, Indonesia
  • Nahwa Arkhaesi Bagian Ilmu Kesehatan Anak, Fakultas Kedokteran, Universitas Diponegoro, Indonesia
  • Dwi Retnoningrum Bagian Patologi Klinik, Fakultas Kedokteran, Universitas Diponegoro, Indonesia

DOI:

https://doi.org/10.36408/mhjcm.v8i2.578

Keywords:

Antibiotic usage; internal medicine; DDD/100 patient–days; Gyssens criteria

Abstract

Background: Inappropriate use of antibiotics could increase the incidence of antibiotic resistance, hence increasing morbidity, mortality, and health cost. WHO has recommended to conduct a study of rational use of antibiotics in order to overcome this problem.

Aim: To analyze the quality and quantity of antibiotic use in inpatient care facility at Diponegoro National Hospital (RSND).

Methods: Quality and quantity assessment conducted by the use of DDD/100 patient–days and the Gyssens criteria. The study was conducted retrospectively at 86 patients’ medical records that were obtained by consecutive sampling method.

Results: There were 141 antibiotics prescriptions from 86 medical records. Azithromycin, levofloxacin, and ceftriaxone were the most commonly used and had 48,12; 44,01; and 21,13 DDD/100 patient–days. By Gyssens crieteria, 35,4% of antibiotic usage was appropriate, 51,1% of antibiotic usage was inappropriate, and 13,5% no indication of the use of antibiotic. Based on the type of therapy, ADE 89,4% and ADET 10,6%.

Conclusion: In terms of quantity, the most commonly used antibiotic was azithromycin. In terms of quality, 35,4% antibiotic were used appropriately according to Gyssens criteria.

 

Keywords: Antibiotic usage; internal medicine; DDD/100 patient–days; Gyssens criteria

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References

World Health Organization (WHO). The World Medicines Situation [Internet]. 2004 [cited 2020 Mar 9]. Available from: https:// www. who.int/ medicines/areas/policy/world_medicines_situation/en.

Gaash B. Irrational use of antibiotics. IJPD. 2008;5(1):2008-3.

Otoom S, Culligan K, Al Assoomi B, Al Ansari T. Analysis of drug prescriptions in primary health care centres in Bahrain. 2010;16(5);511-515.

Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, et al. Antibiotic resistance—the need for global solutions. Lancet Infect Dis. 2013;13(12):1057-98.

Parathon H, Kuntaman K, Widiastoety TH, Muliawan BT, Karuniawati A, Qibtiyah M, et al. Progress towards antimicrobial resistance containment and control in Indonesia. BMJ. 2017;358:j3808.

Ministry of Health Indonesia. Antimicrobial Resistance, Antibiotic Usage and Infection Control. A Self-Assessment Program for Indonesian Hospitals. Jakarta (Indonesia). Ministry of Health Indonesia; 2005.

Ayukekbong JA, Ntemgwa M, Atabe AN. The threat of antimicrobial resistance in developing countries: causes and control strategies. Antimicrob Resist Infect Control. 2017;6(1):47.

Peraturan Menteri Kesehatan Republik Indonesia Nomor 8 Tahun 2015.Program Pengendalian Resistensi Antimikroba Di Rumah Sakit. Jakarta (Indonesia). Kementerian Kesehatan Republik Indonesia; 2015.

Van der Meer J, Gyssens I. Quality of antimicrobial drug prescription in hospital. CMI. 2001;7:12-5.

Lestari PD, Utami ED, Suryoputri MW. Evaluation of Antibiotic Use in Ward of Internal Medicine RSUD Prof. Dr. Margono Soekarjo Purwokerto. Acta Pharm Indones. 2018;6(1):20-8.

Fuentes E, Fuentes M, Alarcon M, Palamo I. Immune system dysfunction in the elderly. An Acad Bras Cienc. 2017;89(1):285-99.

Fatmah F. Low immunity response in the elderly. Makara J Heal Res. 2010;10(1):47-53.

Sukmawati IGAND, Adijaya MK, Swastini DA. Evaluasi Penggunaan Antibiotik pada Pasien Tifoid Rawat Inap di Salah Satu Rumah Sakit Pemerintah Provinsi Bali dengan Metode Gyssens dan ATC/DDD. J Farm Udayana. 2020;9(1):37.

Trumic E, Pranjic N, Begic L, Becic F. Prevalence of polypharmacy and drug interaction among hospitalized patients: opportunities and responsabilities in pharmaceutical care. Mater Socio Medica. 2012;24(2):68.

Abdalla SN, Yousef BA. Prescribing pattern of antimicrobials in the internal medicine department of ibrahim malik teaching hospital in Khartoum, 2016. Pan Afr Med J. 2019;34.

Maraha B, Bonten M, Fiolet H, Stobberingh E. Trends in antibiotic prescribing in general internal medicine wards: Antibiotic use and indication for prescription. Clin Microbiol Infect. 2020;6(1):41-4.

Kartika NTM. Kualitas dan Kuantitas Penggunaan Antibiotik pada Kasus Penyakit Dalam Sebelum dan Setelah Penyuluhan PPRA di RSND [Skripsi]. Semarang (Indonesia): Universitas Diponegoro; 2018.

Bleyzac N, Goutelle S, Bourguignon L, Tod M. Azithromycin for COVID-19: More Than Just an Antimicrobial?. Clin Drug Investig; 2020. 683p.

Karampela I, Dalamaga M. Could Respiratory Fluoroquinolones, Levofloxacin and Moxifloxacin, Prove to be Beneficial as an Adjunct Treatment in COVID-19? Arch Med Res. 2020;51(7);741-2.

Gbinigie K, Frie K. Should azithromycin be used to treat COVID-19? A rapid review. BJGP Open. 2020;4(2).

Martolini D, Galiè M, Santoro AM, Monno D, Santini C, Terracina D. Antibiotic use in departments of internal medicine of Lazio. Ital J Med. 2017;11(4):364-70.

Demoz GT, Kasahun GG, Hagazy K, Woldu G, Wahdey S, Tadesse DB. Prescribing Pattern of Antibiotics Using WHO Prescribing Indicators Among Inpatients in Ethiopia: A Need for Antibiotic Stewardship Program. Infect Drug Resist. 2020; 13:2783-94.

Al-Homaidan HT, Barrimah IE. Physicians’ knowledge, expectations, and practice regarding antibiotic use in primary health care. IJHS. 2018;12(3):18.

Additional Files

Published

2021-07-15

How to Cite

1.
Putra DE, Pramudo SG, Arkhaesi N, Retnoningrum D. ANTIBIOTIC PRESCRIBING PATTERNS DURING THE COVID-19 PANDEMIC (A CASE STUDY AT DIPONEGORO NATIONAL HOSPITAL). Medica Hospitalia J. Clin. Med. [Internet]. 2021 Jul. 15 [cited 2024 Nov. 15];8(2):194-9. Available from: http://medicahospitalia.rskariadi.co.id/medicahospitalia/index.php/mh/article/view/578

Issue

Vol. 8 No. 2 (2021): Med Hosp; Juli 2021

Section

Original Article

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